ヘプロニカート 化学特性,用途語,生産方法
効能
血管拡張薬
商品名
ヘプロニカート (長生堂製薬)
Originator
Megrin,Yoshitomi,Japan,1972
Manufacturing Process
In 50 ml of pyridine were dissolved 50 grams of nicotinic acid and 50 grams
of p-toluene-sulfonyl chloride. While stirring, the mixture gradually became
hot and colorless, and finally solidified. To the mixture was added dropwise a
solution of 19 grams of 2-hexyl-2-(hydroxymethyl)-1,3-propanediol in 400 ml
of pyridine at a temperature below 80°C. The mixture was heated at 115° to
125°C on an oil bath for 1 hour. After cooling, the mixture was poured into
300 ml of ice water, and extracted with toluene. The toluene layer was washed
in sequence with water, aqueous sodium carbonate and water, dried over
potassium carbonate, and then the toluene was distilled off. The oily residue
was crystallized from ethanol to give 30 grams of 2-hexyl-2-(hydroxymethyl)-
1,3-propanediol trinicotinate, melting at 94° to 96°C. The yield was 59.5%.
Therapeutic Function
Vasodilator
ヘプロニカート 上流と下流の製品情報
原材料
準備製品