N,N-ジメチル-N-(2-フェノキシエチル)ベンゼンメタンアミニウム·3-ヒドロキシ-2-ナフトアート 化学特性,用途語,生産方法
使用
antibacterial, antilepretic, antituberculosis
適応症
This drug exhibits antihelmintic action by acting as a cholinergic agonist, causing paralysis
of the parasite musculature. This facilitates its removal from the intestines. It is used for
treating ascariasis, ankylostomiasis, enterobiasis, trichostrongyliasis, and tricocefalosis. A
single dose of bephenium heals from 80 to 100% of patients infected with A. duodenale. It
is less effective with respect to N. americanus. Synonyms of this drug are aclopar and
others.
合成
Bephenium, 3-hydroxy-2-naphthoat benzyldimethyl(2-phenoxyethyl)
ammonia (38.1.37), is made by reacting the sodium salt of 3-hydroxy-2-naphthoic acid
with benzyldimethyl(2-phenoxyethyl)ammonia chloride (38.1.36). This is in turn made
from benzyl chloride and N-(2-phenoxyethyl)dimethylamine (38.1.35), which is synthesized by reacting sodium phenolate with 2-dimethylaminoethylchloride.
N,N-ジメチル-N-(2-フェノキシエチル)ベンゼンメタンアミニウム·3-ヒドロキシ-2-ナフトアート 上流と下流の製品情報
原材料
準備製品