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JW74

化学構造式
863405-60-1
CAS番号.
863405-60-1
化学名:
别名:
英語名:
JW74
英語别名:
JW74;JW74;JW 74;JW74 >=98% (HPLC);Inhibitor,JW74,JW-74,JW 74,inhibit,Wnt;5-(((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)methyl)-3-(p-tolyl)-1,2,4-oxadiazole;4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine;Pyridine, 4-[4-(4-methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-
CBNumber:
CB52731079
化学式:
C24H20N6O2S
分子量:
456.52
MOL File:
863405-60-1.mol

JW74 物理性質

沸点 :
699.4±65.0 °C(Predicted)
比重(密度) :
1.35±0.1 g/cm3(Predicted)
貯蔵温度 :
2-8°C
溶解性:
DMSO：20mg/mL以上
酸解離定数(Pka):
1.63±0.10(Predicted)
外見 :
粉
色:
白からベージュ

安全性情報

WGK Germany  3

JW74 価格 もっと(4)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC5653
JW 74 		863405-60-1 10mg ￥55000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC5653
JW 74 		863405-60-1 50mg ￥225000 2024-03-01 購入
Sigma-Aldrich Japan SML0227 ≥98% (HPLC)
JW74 ≥98% (HPLC)		 863405-60-1 5mg ￥20700 2024-03-01 購入
Sigma-Aldrich Japan SML0227 ≥98% (HPLC)
JW74 ≥98% (HPLC)		 863405-60-1 25mg ￥74900 2023-06-01 購入

JW74 化学特性,用途語,生産方法

説明

Tankyrases (TNKS) are poly(ADP-ribose) polymerases (PARPs) that cleave NAD+ to produce nicotinamide and ADP-ribose, which is then covalently attached to an acceptor protein in a process known as poly(ADP-ribosyl)ation. TNKS have key roles in the Wnt signaling pathway as part of the β-catenin destruction complex. JW 74 is an inhibitor of the catalytic PARP domain of TNKS1/2 that blocks canonical Wnt signaling with an IC50 value of 790 nM. It increases the levels of Axin2 and decreases β-catenin levels in colorectal cancer (CRC) cells, leading to down-regulation of Wnt target genes. JW 74 inhibits the growth of CRC xenograft tumors in mice. JW 74 induces apoptosis and differentiation in osteosarcoma cell lines.

使用

JW 74 is an inhibitor that affects cell cycle progression and induces apoptosis and differentiation in osteosarcoma cell lines.

JW74 上流と下流の製品情報

原材料

準備製品

JW74 生産企業

Global( 48)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32715 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 19892 58
Career Henan Chemica Co 		+86-0371-86658258 15093356674;
 laboratory@coreychem.com China 30255 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd 		+86-19164747840 +86-13119157289
 13119157289@163.com China 2969 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 57511 58
MedChemexpress LLC 021-58955995
sales@medchemexpress.cn United States 4863 58
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185
 sales-cpd@caerulumpharma.com China 3429 58
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9708 58
Changzhou Hopschain Chemical Co.,Ltd. 0519-85528066 13775048983
 sales@hopschem.com China 31557 55
Tianjin Kailiqi Biotechnology Co., Ltd. 15076683720
 klq@cw-bio.com China 3552 55
  • 863405-60-1
  • JW74
  • 4-[4-(4-Methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-pyridine
  • JW74;JW 74
  • Pyridine, 4-[4-(4-methoxyphenyl)-5-[[[3-(4-methylphenyl)-1,2,4-oxadiazol-5-yl]methyl]thio]-4H-1,2,4-triazol-3-yl]-
  • JW74 >=98% (HPLC)
  • Inhibitor,JW74,JW-74,JW 74,inhibit,Wnt
  • 5-(((4-(4-Methoxyphenyl)-5-(pyridin-4-yl)-4H-1,2,4-triazol-3-yl)thio)methyl)-3-(p-tolyl)-1,2,4-oxadiazole
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