8-(4-クロロフェニルチオ)グアノシン 3',5'-(環状)一りん酸ナトリウム 化学特性,用途語,生産方法
外観
白色~わずかにうすい褐色, 粉末
溶解性
水及びエタノールに溶け、アセトンにほとんど溶けない。
用途
シグナル伝達の研究用。
使用上の注意
遮光保存
使用
8-(4-Chlorophenylthio)-guanosine 3′,5′-cyclic monophosphate sodium salt has been used to activate GMP-dependent protein kinase (PKG) in vascular smooth muscle cells (VSMCs).
Biochem/physiol Actions
Membrane-permeable analog of cGMP that does not affect cGMP-regulated phosphodiesterase. A more potent cGMP analog than 8-Br-cGMP due to greater membrane permeability and a higher resistance to hydrolysis by phosphodiesterase. Used as a selective activator of cGMP dependent protein kinase (PKG). Found to be a very potent cyclic nucleotide-gated channel agonist.
8-(4-クロロフェニルチオ)グアノシン 3',5'-(環状)一りん酸ナトリウム 上流と下流の製品情報
原材料
準備製品