ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40)
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) 物理性質
- 貯蔵温度 :
- −20°C
- 外見 :
- グリセリン水溶液
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) 価格
もっと(2)
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
Sigma-Aldrich Japan
|
SAB4503789 |
affinity isolated antibody
Anti-phospho-Tyrosine Hydroxylase (pSer40) antibody produced in rabbit affinity isolated antibody |
|
100μG |
¥97700 |
2024-03-01 |
購入 |
Sigma-Aldrich Japan
|
SAB4503789 |
affinity isolated antibody
Anti-phospho-Tyrosine Hydroxylase (pSer40) antibody produced in rabbit affinity isolated antibody |
|
100ug |
¥73300 |
2018-12-25 |
購入 |
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) 化学特性,用途語,生産方法
一般的な説明
Tyrosine Hydroxylase (TH) is encoded by the gene mapped to human chromosome 11p15.5, close to the insulin (INS) and Harvey-ras-1 (HRAS) genes. The N-terminal end of the protein plays a vital role in maintaining intracellular stability of the enzyme. tyrosine hydroxylase is expressed in various tissues such as brain, adrenal medulla and sympathetically innervated tissues. The enzyme is characterized with a regulatory domain (R), a catalytic domain (C) at N-terminal end, and a coiled-coil domain at the C-terminal end.
Biochem/physiol Actions
Tyrosine Hydroxylase (TH) specifically catalyzes the hydroxylation of the amino acid L-tyrosine to 3, 4-dihydroxy-L-phenylalanine (L-DOPA). TH is a rate-limiting enzyme involved in the synthesis of catecholamine, involved in several brain functions, such as attention, memory, cognition, and emotion. Phosphorylation of the N-terminal portion of tyrosine hydroxylase controls the degradation of this enzyme by the ubiquitin-proteasome pathway. Alteration in the expression of the gene results in the pathogenesis of Parkinson′s disease (PD). Point mutation in the gene coding for TH leads to Segawa′s syndrome.
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) 上流と下流の製品情報
原材料
準備製品
ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40) 生産企業
Global( 4)Suppliers
- ANTI-TYROSINE HYDROXYLASE (PSER40) RABBIT PAB
- ANTI-PHOSPHO-TYROSINE HYDROXYLASE (PSER40)
- ANTI-RAT TYROSINE HYDROXYLASE, PHOSPHOSER 40
- Anti-phospho-Tyrosine Hydroxylase (pSer40) antibody produced in rabbit
- ANTI-TYROSINE HYDROXYLASE, RAT, PHOSPHO-SPECIFIC (SER40), RAT