フェンセリン

フェンセリン 価格 もっと(5)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01BCSQ-1860	Phenserine, (-)-N-Phenylcarbamoyleseroline	101246-66-6	100mg	￥57000	2018-12-26	購入
富士フイルム和光純薬株式会社(wako)	W01BCSQ-1860	Phenserine, (-)-N-Phenylcarbamoyleseroline	101246-66-6	250mg	￥115000	2018-12-26	購入
Sigma-Aldrich Japan	P0111	≥98% (HPLC), solid Phenserine ≥98% (HPLC), solid	101246-66-6	25mg	￥17800	2024-03-01	購入
Sigma-Aldrich Japan	P0111	≥98% (HPLC), solid Phenserine ≥98% (HPLC), solid	101246-66-6	100mg	￥88000	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01TOC2967	フェンセリン Phenserine	101246-66-6	50mg	￥36000	2020-09-21	購入

フェンセリン 化学特性,用途語,生産方法

使用

Phenserine is inhibitor of amyloid precursor protein (APP). Used in Alzheimer’s treatments.

生物活性

Physostigmine analog that inhibits acetylcholinesterase. Inhibits production of amyloid precursor protein (APP) and A β . Improves morris water maze performance of scopolamine-treated rats.

酵素阻害剤

This long-acting AChE inhibitor and A?42-lowering agent (FW = 337,42 g/mol; CAS 101246-66-6), also known as (–) -N-phenylcarbamoyl eseroline, is a carbamate analogue of eserine (or physostigmine) that inhibits acetylcholinesterase and is under active investigation for its potential in cholinomimetic therapy to reduce cognitive impairments associated with aging and Alzheimer's Disease. Phenserine is a potent and highly selective AChE inhibitor (IC50 = 22 nM), displaying 70x greater inhibitory action than observed with butyrylcholinesterase, or BChE (IC50 = 1560 nM), both in vitro and in clinical trials for treatment of Alzheimer's disease (1-5). Compared to physostigmine and tacrine, phenserine appears to be less toxic and robustly enhances cognition in animal models. In rats, phenserine achieves maximum acetylcholinesterase inhibition of 73.5% at 5 min, maintaining high and relatively constant inhibition for >8 hours. Phenserine decreased the levels of secreted b-amyloid precursor protein (b- APP) in the cerebrospinal fluid (CSF) of forebrain cholinergic system- lesioned rats, whereas DFP, a relatively non-specific cholinesterase inhibitor, failed to affect CSF levels of secreted b-APP. Such findings suggest that phenserine alters the induction of cortical b-APP mRNAs and increased levels of secreted b-APP in the CSF. Phenserine reduces Ab levels by regulating b-APP translation via a recently described iron regulatory element in the 5'-untranslated region of b-APP mRNA that was previously shown to be up-regulated in the presence of interleukin-1. Other dual AChE/A?42 inhibitors include: rivastigmine, ladostigil, asenapine, phenserine, amitriptyline, clomipramine, doxepin and desipramine. Posiphen, the better-tolerated (+) -enantiomer of phenserine, is devoid of anticholinesterase action, but represses translation of neural α- synuclein, a druggable target in the treatment of Parkinson Disease.

フェンセリン 上流と下流の製品情報

原材料

準備製品

フェンセリン 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	19892	58
Nextpeptide Inc	+86-0571-81612335 +8613336028439	sales@nextpeptide.com	China	19915	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
SUZHOU SENFEIDA CHEMICAL CO.,LTD	+86-0512-83500002 +8615195660023	sales@senfeida.com	China	23053	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai Eyougene biotechnology development co.LTD	021-52277372 13564545227	dom.sales@eyougene.com	China	245	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15421	60
Hangzhou Yuhao Chemical Technology Co., Ltd	0571-82693216	info@yuhaochemical.com	China	9394	52
EMMX Biotechnology LLC	888-539-0666	info@emmx.com	United States	8449	60

101246-66-6(フェンセリン)キーワード:

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• 101246-66-6
• (3as-cis)-amate(ester
• 3-b)indol-5-ol,1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-pyrrolo(phenylcarb
• (-)-N-PHENYLCARBAMOYLESEROLINE
• PHENSERINE
• (3aS,8aR)-1,2,3,3a,8,8a-Hexahydro-1,3a,8-trimethylpyrrolo[2,3-b]indol-5-ol5-(N-phenylcarbamate)
• 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-pyrrolo[2,3-b]indol-5-ol phenylcarbamate (ester)
• (-)-Eseroline phenylcarbamate
• Pyrrolo[2,3-b]indol-5-ol, 1,2,3,3a,8,8a-hexahydro-1,3a,8-trimethyl-, 5-(N-phenylcarbamate), (3aS,8aR)-
• (-)-Phenserine
• (-)-Eseroline phenylcarbamate
• フェンセリン
• (3aS)-1,2,3,3a,8,8aα-ヘキサヒドロ-1,3aα,8-トリメチルピロロ[2,3-b]インドール-5-オールフェニルカルバマート
• (-)-エセロリンフェニルカルバマート
• (3aS,8aR)-1,3a,8-トリメチル-1H,2H,3H,3aH,8H,8aH-ピロロ[2,3-b]インドール-5-イル N-フェニルカルバマート
• (-)-フェンセリン
• (3aS)-1,3aα,8-トリメチル-5-(フェニルカルバモイルオキシ)-1,2,3,3a,8,8aα-ヘキサヒドロピロロ[2,3-b]インドール