フルラゼパム 化学特性,用途語,生産方法
外観
白色～うすい黄色, 結晶～粉末
溶解性
クロロホルムに極めて溶けやすく、メタノール、エタノール、無水酢酸又はエーテルに溶けやすく、水にほとんど溶けない。エタノール(95)に溶けやすく、水にほとんど溶けない。
用途
ベンゾジアゼピン系化合物で
す。GABA 受容体に作用し、中枢神経抑制作
用を示します。作用時間は長時間です。
用途
ベンゾジアゼピン系化合物で す。GABA受容体に作用し、中枢神経抑制作 用を示します。作用時間は長時間です。
用途
動物実験、薬毒物試験の標準品。
効能
催眠鎮静薬
説明
Flurazepam (CRM) (Item No. 18160) is a certified reference material that is structurally categorized as a benzodiazepine. It acts as a partial agonist of the benzodiazepine site on GABA
A receptors, potentiating the action of GABA with an EC
50 value of 930 nM in neuronal chick spinal cord cultures. Through this signaling mechanism, flurazepam produces anxiolytic and sedative properties that have been implemented clinically in the treatment of insomnia but also carry a potential for misuse. This product is intended for forensic and research purposes.
化学的特性
Flurazepam is a pale yellow crystalline
solid.
使用
Anticonvulsant; relaxant (muscle); sedative-hypnotic Dalmane (Valeant.
薬物動態学
Chlorazepate is yet another
benzodiazepine that is rapidly metabolized (3-decarboxylation) to N-desmethyldiazepam and so shares similar
clinical and pharmacokinetic properties to chlordiazepoxide and diazepam.
副作用
The half-life of flurazepam is fairly long (~7 hours); consequently, it has the same
potential as chlordiazepoxide and diazepam to produce cumulative clinical effects and side effects (e.g., excessive
sedation) and residual pharmacological activity, even after discontinuation.
安全性プロファイル
Poison by intravenous
routes. Moderately toxic by ingestion and subcutaneous routes. Experimental
reproductive effects. Caution: May be habit forming. This is a controlled substance
(depressant) listed in the US. Code of
Federal Regulations, Title 21 Part 1308.14.
When heated to decomposition it emits very
toxic fumes of Cl-, Fand NOx. See also DIAZEPAM.
職業ばく露
A Drug. Flurazepam is used as a seda tive in capsules or liquid form.
代謝
Flurazepam is administered orally as the dihydrochloride salt. It is rapidly 1N-dealkylated to give the 2′-fluoro
derivative of N-desmethyldiazepam, and it subsequently follows the same metabolic pathways as chlordiazepoxide
and diazepam.
輸送方法
UN3249 Medicine, solid, toxic, n.o.s., Hazard
Class: 6.1; Labels: 6.1-Poisonous materials.
廃棄物の処理
It is inappropriate and possi bly dangerous to the environment to dispose of expired or
waste drugs and pharmaceuticals by flushing them down
the toilet or discarding them to the trash. Household quanti ties of expired or waste pharmaceuticals may be mixed
with wet cat litter or coffee grounds, double-bagged in
plastic, discard in trash. Larger quantities shall carefully
take into consideration applicable DEA, EPA, and FDA
regulations. If possible return the pharmaceutical to the
manufacturer for proper disposal being careful to properly
label and securely package the material. Alternatively, the
waste pharmaceutical shall be labeled, securely packaged
and transported by a state licensed medical waste contractor
to dispose by burial in a licensed hazardous or toxic waste
landfill or incinerator.
フルラゼパム 上流と下流の製品情報
原材料
準備製品