抗プレセニリン-1(S182)抗体 ウサギ宿主抗体 化学特性,用途語,生産方法
使用
Anti-Presenilin-1 (S182) antibody produced in rabbit has been used in:
- immunostaining
- immunofluorescence detection
- immunohistochemistry
- immunoblotting
一般的な説明
Presenilin 1& 2 (PS1 and PS2) are highly homologous proteins (approx. 43-52 kD) with eight transmembrane domains. In the brain, PS1 and PS2 are expressed primarily in neurons and localized mainly in cell bodies, axons and dendrites. In non-neuronal cells, PS1 and PS2 are localized to the nuclear membrane, endoplasmic reticulum and Golgi. Presenilin 1 is located on chromosome 14.
Biochem/physiol Actions
The biological functions of the presenilin′s are yet unknown, but they are thought to be involved in protein trafficking. Mutations in the presenilin 1 (PS1) gene (>30 known pathogenic mutations) have been found in about half of the early-onset familial Alzheimer′s disease (FAD), while only two pathogenic mutations have been found in PS2.
抗プレセニリン-1(S182)抗体 ウサギ宿主抗体 上流と下流の製品情報
原材料
準備製品