(-)-SINOACUTINE 化学特性,用途語,生産方法
説明
A morphine type alkaloid isolated from Sinomenium acutum Rehd. and Wils, the base is laevorotatory with[α]
16D - 112° (EtOH) or - 81.60 (CHCI
3). It yields a series of crystalline salts and derivatives including the perchlorate, m.p. 117°C;
tartrate, m.p. 203-4°C; picrate, m.p. 222°C (dec.); oxime, m.p. 223°C and the
methiodide, m.p. 216°C. The alkaloid also forms the O-acetate, m.p. 175°C;
[α]
D - 125° (EtOH) with AC
20 in pyridine, indicative of a phenolic hydroxyl
group. On hydrogenation it forms tetrahydrosinoacutinol, C
19H
270
4N, m.p.
216°C. The O-methyl ether yields a crystalline methiodide which contains
Me
2CO when obtained from this solvent, m.p. 163-6°C. According to Johns and
his co-workers, the alkaloid is also present in Cassytha pubescens R. Br.
参考文献
Chu, Lo, Chou., Acta Chirn. Sinica., 30,265 (1964)
Barton, Korby, Kirby., Chern. Cornrnun., 52 (1965)
Chambers, Haynes, Stuart., ibid, 449 (1966)
Johns, Lamberton, Sioumis., Austral. J. Chern., 19,2331 (1966)
Circular dichroism:
Snatzke, Wollenberg.,l. Chern. Soc., C, 1681 (1966)
(-)-SINOACUTINE 上流と下流の製品情報
原材料
準備製品