(-)-SINOACUTINE Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
A morphine type alkaloid isolated from Sinomenium acutum Rehd. and Wils, the base is laevorotatory with[α]
16D - 112° (EtOH) or - 81.60 (CHCI
3). It yields a series of crystalline salts and derivatives including the perchlorate, m.p. 117°C;
tartrate, m.p. 203-4°C; picrate, m.p. 222°C (dec.); oxime, m.p. 223°C and the
methiodide, m.p. 216°C. The alkaloid also forms the O-acetate, m.p. 175°C;
[α]
D - 125° (EtOH) with AC
20 in pyridine, indicative of a phenolic hydroxyl
group. On hydrogenation it forms tetrahydrosinoacutinol, C
19H
270
4N, m.p.
216°C. The O-methyl ether yields a crystalline methiodide which contains
Me
2CO when obtained from this solvent, m.p. 163-6°C. According to Johns and
his co-workers, the alkaloid is also present in Cassytha pubescens R. Br.
Einzelnachweise
Chu, Lo, Chou., Acta Chirn. Sinica., 30,265 (1964)
Barton, Korby, Kirby., Chern. Cornrnun., 52 (1965)
Chambers, Haynes, Stuart., ibid, 449 (1966)
Johns, Lamberton, Sioumis., Austral. J. Chern., 19,2331 (1966)
Circular dichroism:
Snatzke, Wollenberg.,l. Chern. Soc., C, 1681 (1966)
(-)-SINOACUTINE Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
