H1152二塩酸塩 化学特性,用途語,生産方法
外観
白色〜わずかにうすい黄色, 結晶〜粉末
溶解性
メタノール及び水に溶ける。
使用上の注意
不活性ガス封入
化学的特性
White to Off-White Solid
使用
ROCK Inhibitor. A cell-permeable isoquinolinesulfonamide compoud that acts as a highly specific, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK: Ki=1.6nM). Exhibits a much weaker affinity for other serine/threonine
一般的な説明
A cell-permeable isoquinolinesulfonamide compound that acts as a highly specific, reversible, potent, and ATP-competitive inhibitor of G-protein Rho-associated kinase (ROCK; K
i = 1.6 nM). Exhibits a much weaker affinity for other serine/threonine kinases (K
i = 630 nM for PKA, 9.27 μM for PKC, and 10.1 μM for MLCK). Shown to selectively block lysophosphatidic acid-induced, but not PDBu-induced, phosphorylation of myristoylated alanine-rich C kinase substrate MARCKS (IC
50 = 2.5 μM) in NT-2 cells. Reported to be more potent and selective than Y-27632 (Cat. Nos. 688000 and 688001). Mainly targets Aurora Kinase A, and induces polyploidization of acute megakaryocytic leukemia cells (AMKL). At 10 mM (500 μg/128 μl) solution of Rho Kinase Inhibitor (Cat. No.
555552) in H
2O is also available.
H1152二塩酸塩 上流と下流の製品情報
原材料
準備製品