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KU60019

KU60019 化学構造式
925701-46-8
CAS番号.
925701-46-8
化学名:
KU60019
别名:
KU60019
英語名:
KU 60019
英語别名:
KU-60019 (KU60019;2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl;2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide;(2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide;4-Morpholineacetamide, 2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R,6S)-rel-
CBNumber:
CB72535679
化学式:
C30H33N3O5S
分子量:
547.67
MOL File:
925701-46-8.mol

KU60019 物理性質

沸点 :
786.6±60.0 °C(Predicted)
比重(密度) :
1.314±0.06 g/cm3 (20 ºC 760 Torr)
貯蔵温度 :
Store at -20°C
溶解性:
DMF:20.0(Max Conc. mg/mL);36.52(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.91(Max Conc. mM)
DMSO:75.0(Max Conc. mg/mL);136.94(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);91.3(Max Conc. mM)
外見 :
A crystalline solid
酸解離定数(Pka):
13.52±0.20(Predicted)
色:
Light yellow to khaki

安全性情報

KU60019 価格 もっと(3)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC4176 KU60019
KU 60019 		925701-46-8 5mg ￥44000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TOC4176 KU60019
KU 60019 		925701-46-8 10mg ￥68000 2018-12-26 購入
富士フイルム和光純薬株式会社(wako) W01TOC4176 KU60019
KU 60019 		925701-46-8 25mg ￥169000 2018-12-26 購入

KU60019 化学特性,用途語,生産方法

説明

Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50 = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective or without effect against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro. It produces radiosensitization and increases survival in vivo when administered intra-tumorally in orthotopic xenograft models of glioblastoma multiforme. Ku-60019 is particularly effective in producing lethality in cells with mutant p53 or that are deficient in PTEN.

使用

KU-60019 is a potent and reversible inhibitor of ATM kinase, blocking the phosphorylation of ATM substrate proteins. It sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.

KU60019 上流と下流の製品情報

原材料

準備製品

KU60019 生産企業

Global( 27)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30250 58
Shanxi Xuanran Import and Export Trade Co., Ltd. 		+8617735180244
 mike_yan@xuanranglobal.com CHINA 4022 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43348 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52927 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131980 58
Sichuan Wei Keqi Biological Technology Co., Ltd. 028-81700200 18116577057
 3003855609@qq.com China 7887 56
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8449 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Amatek Scientific Co. Ltd. 0512-56316828
info@amateksci.com China 28817 58
Musechem +1-800-259-7612
info@musechem.com United States 4662 60

KU60019  スペクトルデータ(1HNMR)

KU 60019(925701-46-8)1HNMR
  • 925701-46-8
  • (2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide
  • 2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl
  • KU-60019 (KU60019
  • 4-Morpholineacetamide, 2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R,6S)-rel-
  • 2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide
  • KU60019
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