KU 60019
- CAS No.
- 925701-46-8
- Chemical Name:
- KU 60019
- Synonyms
- KU-60019 (KU60019;2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl;2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide;(2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide;4-Morpholineacetamide, 2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R,6S)-rel-
- CBNumber:
- CB72535679
- Molecular Formula:
- C30H33N3O5S
- Molecular Weight:
- 547.67
- MDL Number:
- MFCD18384974
- MOL File:
- 925701-46-8.mol
- MSDS File:
- SDS
| Boiling point | 786.6±60.0 °C(Predicted) |
|---|---|
| Density | 1.314±0.06 g/cm3 (20 ºC 760 Torr) |
| storage temp. | Store at -20°C |
| solubility |
DMF:20.0(Max Conc. mg/mL);36.52(Max Conc. mM) DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.91(Max Conc. mM) DMSO:75.0(Max Conc. mg/mL);136.94(Max Conc. mM) Ethanol:50.0(Max Conc. mg/mL);91.3(Max Conc. mM) |
| form | A crystalline solid |
| pka | 13.52±0.20(Predicted) |
| color | Light yellow to khaki |
KU 60019 price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 17502 | Ku-60019 | 925701-46-8 | 1mg | $29 | 2024-03-01 | Buy |
| Cayman Chemical | 17502 | Ku-60019 | 925701-46-8 | 25mg | $250 | 2024-03-01 | Buy |
| Cayman Chemical | 17502 | Ku-60019 | 925701-46-8 | 5mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 17502 | Ku-60019 | 925701-46-8 | 10mg | $143 | 2024-03-01 | Buy |
| TRC | K660435 | KU-60019 | 925701-46-8 | 10mg | $235 | 2021-12-16 | Buy |
KU 60019 Chemical Properties,Uses,Production
Description
Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50 = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective or without effect against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro. It produces radiosensitization and increases survival in vivo when administered intra-tumorally in orthotopic xenograft models of glioblastoma multiforme. Ku-60019 is particularly effective in producing lethality in cells with mutant p53 or that are deficient in PTEN.
Uses
KU-60019 is a potent and reversible inhibitor of ATM kinase, blocking the phosphorylation of ATM substrate proteins. It sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro.
KU 60019 Preparation Products And Raw materials
Raw materials
Preparation Products
KU 60019 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30254 | 58 |
| Shanxi Xuanran Import and Export Trade Co., Ltd. | +8617735180244 | mike_yan@xuanranglobal.com | CHINA | 4022 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43348 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9708 | 58 |
| Amatek Scientific Co. Ltd. | 0512-56316828 | info@amateksci.com | China | 28820 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4662 | 60 |