KU 60019
|
- $29 - $2200
- Product name: KU 60019
- CAS: 925701-46-8
- MF: C30H33N3O5S
- MW: 547.67
- EINECS:
- MDL Number:MFCD18384974
- Synonyms:(2R,6S)-rel-2,6-Dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-4-morpholineacetamide;2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl;KU-60019 (KU60019;4-Morpholineacetamide, 2,6-dimethyl-N-[5-[6-(4-morpholinyl)-4-oxo-4H-pyran-2-yl]-9H-thioxanthen-2-yl]-, (2R,6S)-rel-;2-((2R,6S)-2,6-Dimethylmorpholino)-N-(5-(6-morpholino-4-oxo-4H-pyran-2-yl)-9H-thioxanthen-2-yl)acetamide
18 prices
Selected condition：
Brand
- AK Scientific
- Biosynth Carbosynth
- Cayman Chemical
- ChemScene
- Crysdot
- DC Chemicals
- TRC
Package
- 1mg
- 5mg
- 10mg
- 25mg
- 50mg
- 100mg
- 250mg
- 1g
- ManufacturerAK Scientific
- Product numberX7426
- Product descriptionKU-60019
- Packaging50mg
- Price$512
- Updated2021-12-16
- Buy
- ManufacturerAK Scientific
- Product numberX7426
- Product descriptionKU-60019
- Packaging100mg
- Price$820
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFK145340
- Product descriptionKU 60019
- Packaging10mg
- Price$105
- Updated2021-12-16
- Buy
- ManufacturerBiosynth Carbosynth
- Product numberFK145340
- Product descriptionKU 60019
- Packaging50mg
- Price$325
- Updated2021-12-16
- Buy
- ManufacturerCayman Chemical
- Product number17502
- Product descriptionKu-60019
- Packaging1mg
- Price$29
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17502
- Product descriptionKu-60019
- Packaging5mg
- Price$115
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17502
- Product descriptionKu-60019
- Packaging10mg
- Price$143
- Updated2024-03-01
- Buy
- ManufacturerCayman Chemical
- Product number17502
- Product descriptionKu-60019
- Packaging25mg
- Price$250
- Updated2024-03-01
- Buy
- ManufacturerChemScene
- Product numberCS-0221
- Product descriptionKU-60019 99.43%
- Packaging5mg
- Price$84
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0221
- Product descriptionKU-60019 99.43%
- Packaging10mg
- Price$119
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0221
- Product descriptionKU-60019 99.43%
- Packaging50mg
- Price$360
- Updated2021-12-16
- Buy
- ManufacturerChemScene
- Product numberCS-0221
- Product descriptionKU-60019 99.43%
- Packaging100mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000231
- Product descriptionKU60019 98+%
- Packaging50mg
- Price$405
- Updated2021-12-16
- Buy
- ManufacturerCrysdot
- Product numberCD31000231
- Product descriptionKU60019 98+%
- Packaging100mg
- Price$666
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7448
- Product descriptionKU-60019 >98%
- Packaging100mg
- Price$600
- Updated2021-12-16
- Buy
- ManufacturerDC Chemicals
- Product numberDC7448
- Product descriptionKU-60019 >98%
- Packaging250mg
- Price$1100
- Updated2021-12-16
- Buy
| Manufacturer | Product number | Product description | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|
| AK Scientific | X7426 | KU-60019 | 50mg | $512 | 2021-12-16 | Buy |
| AK Scientific | X7426 | KU-60019 | 100mg | $820 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FK145340 | KU 60019 | 10mg | $105 | 2021-12-16 | Buy |
| Biosynth Carbosynth | FK145340 | KU 60019 | 50mg | $325 | 2021-12-16 | Buy |
| Cayman Chemical | 17502 | Ku-60019 | 1mg | $29 | 2024-03-01 | Buy |
| Cayman Chemical | 17502 | Ku-60019 | 5mg | $115 | 2024-03-01 | Buy |
| Cayman Chemical | 17502 | Ku-60019 | 10mg | $143 | 2024-03-01 | Buy |
| Cayman Chemical | 17502 | Ku-60019 | 25mg | $250 | 2024-03-01 | Buy |
| ChemScene | CS-0221 | KU-60019 99.43% | 5mg | $84 | 2021-12-16 | Buy |
| ChemScene | CS-0221 | KU-60019 99.43% | 10mg | $119 | 2021-12-16 | Buy |
| ChemScene | CS-0221 | KU-60019 99.43% | 50mg | $360 | 2021-12-16 | Buy |
| ChemScene | CS-0221 | KU-60019 99.43% | 100mg | $600 | 2021-12-16 | Buy |
| Crysdot | CD31000231 | KU60019 98+% | 50mg | $405 | 2021-12-16 | Buy |
| Crysdot | CD31000231 | KU60019 98+% | 100mg | $666 | 2021-12-16 | Buy |
| DC Chemicals | DC7448 | KU-60019 >98% | 100mg | $600 | 2021-12-16 | Buy |
| DC Chemicals | DC7448 | KU-60019 >98% | 250mg | $1100 | 2021-12-16 | Buy |
Properties
Boiling point :786.6±60.0 °C(Predicted)
Density :1.314±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :Store at -20°C
solubility :DMF:20.0(Max Conc. mg/mL);36.52(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.91(Max Conc. mM)
DMSO:75.0(Max Conc. mg/mL);136.94(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);91.3(Max Conc. mM) form :A crystalline solid
pka :13.52±0.20(Predicted)
color :Light yellow to khaki
Density :1.314±0.06 g/cm3 (20 ºC 760 Torr)
storage temp. :Store at -20°C
solubility :DMF:20.0(Max Conc. mg/mL);36.52(Max Conc. mM)
DMF:PBS (pH 7.2) (1:1):0.5(Max Conc. mg/mL);0.91(Max Conc. mM)
DMSO:75.0(Max Conc. mg/mL);136.94(Max Conc. mM)
Ethanol:50.0(Max Conc. mg/mL);91.3(Max Conc. mM) form :A crystalline solid
pka :13.52±0.20(Predicted)
color :Light yellow to khaki
Safety Information
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Description
Ataxia-telangiectasia mutated (ATM) is a serine/threonine kinase that activates checkpoint signaling following double strand DNA breaks and genotoxic stress. Ku-60019 is a potent, reversible inhibitor of ATM kinase (IC50 = 6.3 nM), blocking the phosphorylation of ATM substrate proteins. It is much less effective or without effect against a panel of 229 other kinases. Ku-60019 sensitizes glioma cells to radiation and inhibits migration and invasion of glioma cells in vitro. It produces radiosensitization and increases survival in vivo when administered intra-tumorally in orthotopic xenograft models of glioblastoma multiforme. Ku-60019 is particularly effective in producing lethality in cells with mutant p53 or that are deficient in PTEN.Suppliers and manufacturers
Career Henan Chemica Co
Shanxi Xuanran Import and Export Trade Co., Ltd.
LEAPCHEM CO., LTD.
Aladdin Scientific
Amadis Chemical Company Limited
Sichuan Wei Keqi Biological Technology Co., Ltd.
EMMX Biotechnology LLC
Shanghai EFE Biological Technology Co., Ltd.
Amatek Scientific Co. Ltd.
