Chinese english Germany Korea

Phthalazinone pyrazole

化学構造式
880487-62-7
CAS番号.
880487-62-7
化学名:
别名:
英語名:
Phthalazinone pyrazole
英語别名:
Phthalazinone pyrazole;Phthalazinone pyrazole Exclusive;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one;4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one;1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1,2-dihydrophthalazin-1-one;Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition
CBNumber:
CB72592005
化学式:
C18H15N5O
分子量:
317.34
MOL File:
880487-62-7.mol

Phthalazinone pyrazole 物理性質

沸点 :
557.7±52.0 °C(Predicted)
比重(密度) :
1.35±0.1 g/cm3(Predicted)
貯蔵温度 :
Store at -20°C
溶解性:
insoluble in EtOH; insoluble in H2O; ≥7.14 mg/mL in DMSO
外見 :
crystalline solid
酸解離定数(Pka):
13.83±0.10(Predicted)
色:
Brown to gray

安全性情報

Phthalazinone pyrazole 価格

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入

Phthalazinone pyrazole 化学特性,用途語,生産方法

説明

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors. Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC50 = 31 nM). It does not inhibit Aurora B kinase at doses up to 100 μM. Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC50 = 7.8, 2.9, and 1.6 μM, respectively).

Phthalazinone pyrazole 上流と下流の製品情報

原材料

準備製品

Phthalazinone pyrazole 生産企業

Global( 35)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32820 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32038 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3135 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4456 55
ShangHai Biochempartner Co.,Ltd 177-54423994 17754423994
 2853530910@QQ.com China 8014 62
Shanghai Rechem science Co., Ltd. 21-31433387 15618786686
 sales@rechemscience.com China 2983 58
Shanghai Chaolan Chemical Technology Center QQ:65489617 15618227136
 info@SuperLan-chem.com China 6527 58
Shanghai Yu Ben Biotechnology Co., Ltd. 15502154572
 yuben012@sina.com China 506 58
DC Chemicals 021-58447131 13564518121
 sales@dcchemicals.com China 9410 58

  スペクトルデータ(1HNMR)

Phthalazinone pyrazole(880487-62-7)1HNMR
  • 880487-62-7
  • Phthalazinone pyrazole
  • Phthalazinone pyrazole Exclusive
  • 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one
  • 1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-
  • 4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one
  • Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition
  • 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1,2-dihydrophthalazin-1-one
Copyright 2017 © ChemicalBook. All rights reserved