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프탈라지논피라졸

프탈라지논피라졸 구조식 이미지

카스 번호:: 880487-62-7

한글명:: 프탈라지논피라졸

동의어(한글):: 프탈라지논피라졸

상품명:: Phthalazinone pyrazole

동의어(영문):: Phthalazinone pyrazole;Phthalazinone pyrazole Exclusive;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenylphthalazin-1-one;4-[(5-Methyl-1H-pyrazol-3-yl)amino]-2-phenyl-2H-phthalazin-1-one;1(2H)-Phthalazinone, 4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-;4-[(5-methyl-1H-pyrazol-3-yl)amino]-2-phenyl-1,2-dihydrophthalazin-1-one;Phthalazinone pyrazole,inhibit,human embryonic stem cells,Aurora Kinase,hepatocyte-like cell,Inhibitor,HLCs,Aurora-A kinase,EMT,apoptosis,tumor growth,oral,epithelial-mesenchymal transition

CBNumber:: CB72592005

분자식:: C18H15N5O

포뮬러 무게:: 317.34

MOL 파일:: 880487-62-7.mol

속성

안전

용도

공급 업체 35

프탈라지논피라졸 속성

끓는 점: 557.7±52.0 °C(Predicted)

밀도: 1.35±0.1 g/cm3(Predicted)

저장 조건: Store at -20°C

용해도: insoluble in EtOH; insoluble in H2O; ≥7.14 mg/mL in DMSO

물리적 상태: 결정질 고체

산도 계수 (pKa): 13.83±0.10(Predicted)

색상: Brown to gray

안전

프탈라지논피라졸 C화학적 특성, 용도, 생산

개요

Three Aurora kinases, A-C, are involved in phosphorylation events that are critical for the completion of mitosis. Aurora A, involved in centrosomal assembly and acentrosomal spindle assembly, is overexpressed in many tumors. Phthalazinone pyrazole is a potent inhibitor of Aurora A kinase (IC₅₀ = 31 nM). It does not inhibit Aurora B kinase at doses up to 100 μM. Phthalazinone pyrazole inhibits the proliferation of HCT116, COLO 205, and MCF-7 cells (IC₅₀ = 7.8, 2.9, and 1.6 μM, respectively).

프탈라지논피라졸 준비 용품 및 원자재

원자재

준비 용품

프탈라지논피라졸 공급 업체

글로벌( 35)공급 업체

공급자	전화	이메일	국가	제품 수	이점
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32820	60
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32038	58
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49734	58
Nantong HI-FUTURE Biology Co., Ltd.	+undefined18051384581	sales@chemhifuture.com	China	3135	58
Shanghai Lollane Biological Technology Co.,Ltd.	021-52996696，15000506266 15000506266		China	4456	55
ShangHai Biochempartner Co.,Ltd	177-54423994 17754423994	2853530910@QQ.com	China	8014	62
Shanghai Rechem science Co., Ltd.	21-31433387 15618786686	sales@rechemscience.com	China	2983	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	6527	58
Shanghai Yu Ben Biotechnology Co., Ltd.	15502154572	yuben012@sina.com	China	506	58
DC Chemicals	021-58447131 13564518121	sales@dcchemicals.com	China	9410	58