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SKA-121

化学構造式
1820708-73-3
CAS番号.
1820708-73-3
化学名:
别名:
英語名:
SKA-121
英語别名:
SKA-121;SKA121,SKA 121;Naphth[2,1-d]oxazol-2-amine, 5-methyl-;SKA-121 5-Methylnaphtho[2,1-d]oxazol-2-amin
CBNumber:
CB74667080
化学式:
C12H10N2O
分子量:
198.22
MOL File:
1820708-73-3.mol

SKA-121 物理性質

沸点 :
403.2±38.0 °C(Predicted)
比重(密度) :
1.302±0.06 g/cm3(Predicted)
貯蔵温度 :
2-8°C
溶解性:
DMF: 50 mg/ml; DMSO: 50 mg/ml; DMSO:PBS (pH 7.2) (1:1): 0.5 mg/ml; Ethanol: 10 mg/ml
外見 :
粉
酸解離定数(Pka):
4.48±0.30(Predicted)
色:
ブラウンからダークグレー

安全性情報

SKA-121 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan SML2206 ≥98% (HPLC)
SKA-121 ≥98% (HPLC)		 1820708-73-3 5mg ￥20500 2024-03-01 購入
Sigma-Aldrich Japan SML2206 ≥98% (HPLC)
SKA-121 ≥98% (HPLC)		 1820708-73-3 25mg ￥64100 2024-03-01 購入

SKA-121 化学特性,用途語,生産方法

Biochem/physiol Actions

SKA-121 is a KCa3.1 (IKCa1, IK1, KCa4, SKCa4, SK4) subtype-selective small conductance Ca2+-activated K+ channel (SK channel) positive-gating modulator (EC50 = 109 nM/KCa3.1 vs. 8.7 μM/KCa2.1, 6.8 μM/KCa2.2, 4.4 μM/KCa2.3) with 200- to 400-fold selectivity over CaV1.2 as well as representative KVs (KV1.3, KV2.1, KV3.1, and KV11.1) and NaV (NaV1.2, NaV1.4, NaV1.5, and NaV1.7) channels. When applied in vivo, SKA-121 significantly lowers mean arterial blood pressure in wild-type, but not KCa3.1(-/-), normotensive and hypertensive mice (100 mg/kg i.p.). SKA-121 is a more potent and selective KCa3.1 activator than SKA-31 (EC50 = 260 nM/KCa3.1, 2.9 μM/KCa2.1, 1.9 μM/KCa2.2, 2.9 μM/KCa2.3).

SKA-121 上流と下流の製品情報

原材料

準備製品

SKA-121 生産企業

Global( 31)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
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TargetMol Chemicals Inc.
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Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998
 757984502@qq.com China 892 58
Aladdin Scientific 		+1-+1(833)-552-7181
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BOC Sciences 1-631-485-4226; 16314854226
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Sigma-Aldrich 021-61415566 800-8193336
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Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
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Shanghai Rechem science Co., Ltd. 21-31433387 15618786686
 sales@rechemscience.com China 2982 58
Fan De(Beijing) Biotechnology Co., Ltd. 15911056312
 liming@bio-fount.com China 9729 58
Nanjing Meihao Pharmaceutical Technology Co., Ltd. meitaochem@126.com
meitaochem@126.com China 19103 58
  • 1820708-73-3
  • SKA-121
  • Naphth[2,1-d]oxazol-2-amine, 5-methyl-
  • SKA-121 5-Methylnaphtho[2,1-d]oxazol-2-amin
  • SKA121,SKA 121
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