ChemicalBook >> CAS DataBase List >>SKA-121
SKA-121
- CAS No.
- 1820708-73-3
- Chemical Name:
- SKA-121
- Synonyms
- SKA-121;SKA121,SKA 121;Naphth[2,1-d]oxazol-2-amine, 5-methyl-;SKA-121 5-Methylnaphtho[2,1-d]oxazol-2-amin
- CBNumber:
- CB74667080
- Molecular Formula:
- C12H10N2O
- Molecular Weight:
- 198.22
- MDL Number:
- MFCD31630822
- MOL File:
- 1820708-73-3.mol
- MSDS File:
- SDS
Last updated:2023-07-12 17:01:48
SKA-121 price More Price(16)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | SML2206 | SKA-121 ≥98% (HPLC) | 1820708-73-3 | 5mg | $105 | 2024-03-01 | Buy |
Sigma-Aldrich | SML2206 | SKA-121 ≥98% (HPLC) | 1820708-73-3 | 25mg | $338 | 2024-03-01 | Buy |
Cayman Chemical | 9003088 | SKA-121 ≥98% | 1820708-73-3 | 1mg | $27 | 2024-03-01 | Buy |
Cayman Chemical | 9003088 | SKA-121 ≥98% | 1820708-73-3 | 25 mg | $565 | 2024-03-01 | Buy |
Cayman Chemical | 9003088 | SKA-121 ≥98% | 1820708-73-3 | 500μg | $43 | 2023-01-06 | Buy |
SKA-121 Chemical Properties,Uses,Production
Biochem/physiol Actions
SKA-121 is a KCa3.1 (IKCa1, IK1, KCa4, SKCa4, SK4) subtype-selective small conductance Ca2+-activated K+ channel (SK channel) positive-gating modulator (EC50 = 109 nM/KCa3.1 vs. 8.7 μM/KCa2.1, 6.8 μM/KCa2.2, 4.4 μM/KCa2.3) with 200- to 400-fold selectivity over CaV1.2 as well as representative KVs (KV1.3, KV2.1, KV3.1, and KV11.1) and NaV (NaV1.2, NaV1.4, NaV1.5, and NaV1.7) channels. When applied in vivo, SKA-121 significantly lowers mean arterial blood pressure in wild-type, but not KCa3.1(-/-), normotensive and hypertensive mice (100 mg/kg i.p.). SKA-121 is a more potent and selective KCa3.1 activator than SKA-31 (EC50 = 260 nM/KCa3.1, 2.9 μM/KCa2.1, 1.9 μM/KCa2.2, 2.9 μM/KCa2.3).
storage
Store at -20°C
SKA-121 Preparation Products And Raw materials
Raw materials
Preparation Products
SKA-121 Suppliers
Global( 29)Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd | +86-18341751992 +86-15382112998 | 757984502@qq.com | China | 892 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
BOC Sciences | 1-631-485-4226; 16314854226 | info@bocsci.com | United States | 14059 | 65 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2988 | 58 |
Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9730 | 58 |
Nanjing Meihao Pharmaceutical Technology Co., Ltd. | meitaochem@126.com | meitaochem@126.com | China | 19105 | 58 |
DC Chemicals | 021-58447131 13564518121 | sales@dcchemicals.com | China | 9412 | 58 |
SKA-121
Naphth[2,1-d]oxazol-2-amine, 5-methyl-
SKA-121 5-Methylnaphtho[2,1-d]oxazol-2-amin
SKA121,SKA 121
1820708-73-3