CHPG
CHPG 物理性質
- 沸点 :
- 407.3±45.0 °C(Predicted)
- 比重(密度) :
- 1.531±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- 2-8°C
- 溶解性:
- DMSO：10mg/mL以上
- 外見 :
- ベタ &_& ホワイトベタ
- 酸解離定数(Pka):
- 1.61±0.10(Predicted)
- 色:
- 白い
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC1049 |
CHPG |
170846-74-9 |
10mg |
￥43000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01TOC1049 |
CHPG |
170846-74-9 |
50mg |
￥181000 |
2024-03-01 |
購入 |
|
Sigma-Aldrich Japan
|
C7743 |
≥98% (HPLC), white solid
CHPG ≥98% (HPLC), white solid |
170846-74-9 |
5mg |
￥29300 |
2018-12-25 |
購入 |
|
Sigma-Aldrich Japan
|
C7743 |
≥98% (HPLC), white solid
CHPG ≥98% (HPLC), white solid |
170846-74-9 |
25mg |
￥134900 |
2018-12-25 |
購入 |
CHPG 化学特性,用途語,生産方法
説明
(R,S)-CHPG is a potent and selective agonist at metabotropic glutamate receptor 5 (mGluR5). In CHO cells, it had an EC
50 of 750 μM for calcium mobilization in mGluR5a-expressing cells but was inactive in mGluR1a-expressing cells. In transfected HEK293 cells, (R,S)-CHPG bound mGluR1a and mGluR5a (K
is = 0.9 and 3.9 μM, respectively) but not ionotropic glutamate receptors. It reduced oxidative stress and inflammatory markers in cultured BV-2 microglial cells. In mouse models of traumatic brain injury, it reduced lesion volume, improved sensorimotor deficits in the beam walk test, and improved spatial memory in the Morris water maze.
使用
CHPG is a selective mGluR-5 agonist.
生物活性
A selective mGlu 5 metabotropic glutamate receptor agonist, completely inactive at mGlu 1a receptors expressed in CHO cells. Active in vivo .
CHPG 上流と下流の製品情報
原材料
準備製品
CHPG 生産企業
Global( 41)Suppliers
- 170846-74-9
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- (RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid
- α-amino-2-chloro-5-hydroxybenzeneacetic acid
- (RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE
- CHPG
- Benzeneacetic acid, α-amino-2-chloro-5-hydroxy-