CHPG
|
|
|
- CAS号:
- 170846-74-9
- 英文名:
- CHPG
- 英文别名:
- CHPG;(RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE;α-amino-2-chloro-5-hydroxybenzeneacetic acid;Benzeneacetic acid, α-amino-2-chloro-5-hydroxy-;(RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid;α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine
- 中文名:
- CHPG
- 中文别名:
- 化合物 CHPG;化合物 T10809;(R,S)-CHPG,MGLU 5激动剂
- CBNumber:
- CB7723281
- 分子式:
- C8H8ClNO3
- 分子量:
- 201.61
- MOL File:
- 170846-74-9.mol
|
|
|
CHPG化学性质
-
沸点:
-
407.3±45.0 °C(Predicted)
-
|
-
密度:
-
1.531±0.06 g/cm3(Predicted)
-
|
-
储存条件:
-
2-8°C
-
|
-
溶解度:
-
DMSO: ≥10mg/mL
-
|
-
形态:
-
solid &_& white solid
-
|
-
酸度系数(pKa):
-
1.61±0.10(Predicted)
-
|
-
颜色:
-
white
-
|
CHPG性质、用途与生产工艺
CHPG 是一个选择性的 mGluR5 激动剂，并且通过 TSG-6/NF-κB 途径减弱 BV2 小神经胶质细胞 SO2 诱导的氧化应激和炎症。 CHPG 通过 ERK 和 Akt 途径在体外和体内预防创伤性脑损伤 (TBI)。
CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO
2
derivatives treatment.
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO
2
-induced apoptosis.
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay
|
Cell Line:
|
BV2 microglial cells
|
|
Concentration:
|
10, 50, 100 and 500 µM
|
|
Incubation Time:
|
24 hours
|
|
Result:
|
Increased the cell viability.
|
Apoptosis Analysis
|
Cell Line:
|
BV2 microglial cells
|
|
Concentration:
|
0.5 mM
|
|
Incubation Time:
|
30 mins
|
|
Result:
|
Protected BV2 cells against SO
2
-induced apoptosis.
|
Western Blot Analysis
|
Cell Line:
|
BV2 microglial cells
|
|
Concentration:
|
0.5 mM
|
|
Incubation Time:
|
30 mins
|
|
Result:
|
Increased the expression of TSG-6 in both mRNA and protein levels.
|
CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.
|
Animal Model:
|
Adult Sprague-Dawley male rats weighing 280-320 g
|
|
Dosage:
|
250 nM
|
|
Administration:
|
Injection; for 7 days
|
|
Result:
|
Reduced significantly cerebral lesion volume.
|
CHPG
上下游产品信息
上游原料
下游产品
| 更新日期 | 产品编号 | 产品名称 | CAS编号 | 包装 | 价格 |
|---|
| 2024/11/08 | HY-101364 | CHPG | | 1 mg | 1636元 |
| 2024/11/08 | HY-101364 | CHPG
CHPG | 170846-74-9 | 5mg | 3600元 |
CHPG
生产厂家
全球有 42家供应商
CHPG国内生产厂家
170846-74-9, CHPG 相关搜索:
- Glutamate receptor
- 抑制剂
- 合成有机化合物配体
- 化合物 CHPG
- (R,S)-CHPG,MGLU 5激动剂
- 化合物 T10809
- 170846-74-9
- Benzeneacetic acid, α-amino-2-chloro-5-hydroxy-
- CHPG
- (RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE
- α-amino-2-chloro-5-hydroxybenzeneacetic acid
- (RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid
- α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine