CHPG
中文名称 | CHPG |
---|---|
中文同义词 | 化合物 T10809;(R,S)-CHPG,MGLU 5激动剂 |
英文名称 | CHPG |
英文同义词 | α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine;(RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid;α-amino-2-chloro-5-hydroxybenzeneacetic acid;(RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE;CHPG;Benzeneacetic acid, α-amino-2-chloro-5-hydroxy- |
CAS号 | 170846-74-9 |
分子式 | C8H8ClNO3 |
分子量 | 201.61 |
EINECS号 | |
相关类别 | Glutamate receptor |
Mol文件 | 170846-74-9.mol |
结构式 |
CHPG 性质
沸点 | 407.3±45.0 °C(Predicted) |
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密度 | 1.531±0.06 g/cm3(Predicted) |
储存条件 | 2-8°C |
溶解度 | 二甲基亚砜:≥10mg/mL |
形态 | 固体&_&白色固体 |
酸度系数(pKa) | 1.61±0.10(Predicted) |
颜色 | 白色 |
mGlu 5
|
NF-κB
|
ERK
|
Akt
|
CHPG (10-500 µM; 24 hours) significantly increases the cell viability and decreases the LDH release after SO
2
derivatives treatment.
CHPG (0.5 mM; 30 mins ) protects BV2 cells against SO
2
-induced apoptosis.
CHPG (0.5 mM; 30 mins) treatment alone increases the expression of TSG-6 in both mRNA and protein levels.
Cell Viability Assay
Cell Line: | BV2 microglial cells |
Concentration: | 10, 50, 100 and 500 µM |
Incubation Time: | 24 hours |
Result: | Increased the cell viability. |
Apoptosis Analysis
Cell Line: | BV2 microglial cells |
Concentration: | 0.5 mM |
Incubation Time: | 30 mins |
Result: | Protected BV2 cells against SO 2 -induced apoptosis. |
Western Blot Analysis
Cell Line: | BV2 microglial cells |
Concentration: | 0.5 mM |
Incubation Time: | 30 mins |
Result: | Increased the expression of TSG-6 in both mRNA and protein levels. |
CHPG (injection; 250 nM; for 7 days) reduces significantly cerebral lesion volume.
Animal Model: | Adult Sprague-Dawley male rats weighing 280-320 g |
Dosage: | 250 nM |
Administration: | Injection; for 7 days |
Result: | Reduced significantly cerebral lesion volume. |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/08/19 | HY-101364 | CHPG | 1 mg | 1636元 | |
2024/08/19 | HY-101364 | CHPG CHPG | 170846-74-9 | 5mg | 3600元 |