| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:CHPG;(RS)-2-Chloro-5-hydroxyphenylglycine
CAS:170846-74-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
| Company Name: |
BOC Sciences
|
| Tel: |
1-631-485-4226; 16314854226 |
| Email: |
info@bocsci.com |
| Products Intro: |
Product Name:CHPG
CAS:170846-74-9
Purity:99% by HPLC Remarks:CHPG is a selective metabotropic glutamate 5 (mGlu5) receptor agonist, and it is inactive in CHO cells. CHPG potentiates NMDA-induced depolarizations in rat hippocampal slices, and promotes proliferat
|
|
| Product Name: | CHPG | | Synonyms: | α-Amino-2-chloro-5-hydroxybenzeneacetic acid, (RS)-2-Chloro-5-hydroxyphenylglycine;(RS)-2-chloro-5-hydroxyphenylglycine α-amino-2-chloro-5-hydroxybenzeneacetic acid;α-amino-2-chloro-5-hydroxybenzeneacetic acid;(RS)-2-CHLORO-5-HYDROXYPHENYLGLYCINE;CHPG;Benzeneacetic acid, α-amino-2-chloro-5-hydroxy- | | CAS: | 170846-74-9 | | MF: | C8H8ClNO3 | | MW: | 201.61 | | EINECS: | | | Product Categories: | Glutamate receptor | | Mol File: | 170846-74-9.mol |  |
| Boiling point | 407.3±45.0 °C(Predicted) | | density | 1.531±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ≥10mg/mL | | form | solid &_& white solid | | pka | 1.61±0.10(Predicted) | | color | white |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 26 | | WGK Germany | 3 |
| Description | (R,S)-CHPG is a potent and selective agonist at metabotropic glutamate receptor 5 (mGluR5). In CHO cells, it had an EC50 of 750 μM for calcium mobilization in mGluR5a-expressing cells but was inactive in mGluR1a-expressing cells. In transfected HEK293 cells, (R,S)-CHPG bound mGluR1a and mGluR5a (Kis = 0.9 and 3.9 μM, respectively) but not ionotropic glutamate receptors. It reduced oxidative stress and inflammatory markers in cultured BV-2 microglial cells. In mouse models of traumatic brain injury, it reduced lesion volume, improved sensorimotor deficits in the beam walk test, and improved spatial memory in the Morris water maze. | | Uses | CHPG is a selective mGluR-5 agonist. | | Biological Activity | A selective mGlu 5 metabotropic glutamate receptor agonist, completely inactive at mGlu 1a receptors expressed in CHO cells. Active in vivo . | | in vitro | (r,s)-2-chloro-5-hydroxyphenylglycine [chpg] selectively activated mglu5a receptors with no activation of mglu1a receptors. this selective mglu5 receptor agonist also enhances nmda-induced depolarizations in rat hippocampalslices. chpg may be used to study the role of mglu5 receptors in the cns [1]. | | in vivo | to compare the effects of treatment with the newly developed selective mglur5 antagonist mpep and the selective mglur5 agonist chpg in a rat intraluminal filament model of temporary middle cerebral artery occlusion (mcao), rats, after induction of ischemia for 2 h, were administered mpep or chpg (i.c.v.) beginning 15 or 135 min. measured after either 22 or 70 h of reperfusion measured infarct size, and quantified neurological function at 2, 24, 48 and 72 h. 24 h infarct volumes after treatment with mpep or chpg at 15 min were reduced by 61 and 44%, respectively. the neuroprotective effects were dose-dependent. the neuroprotective effects were eliminated by delaying mpep treatment until 135 min. in other studies, with early mpep treatment (15 min) at optimal doses, infarct volume was reduced by 44% at 72 h, being correlated with significant neurological recovery [2]. | | storage | +4°C (desiccate) | | references | [1] doherty aj, palmer mj, henley jm, collingridge gl, jane de. (rs)-2-chloro-5-hydroxyphenylglycine (chpg) activates mglu5, but no mglu1, receptors expressed in cho cells and potentiates nmda responses in the hippocampus. neuropharmacology. 1997 feb;36(2):265-7.
[2]. bao wl, williams aj, faden ai, tortella fc. selective mglur5 receptor antagonist or agonist provides neuroprotection in a rat model of focal cerebral ischemia. brain res. 2001 dec 20;922(2):173-9. |
| | CHPG Preparation Products And Raw materials |
|