キシメラガトラン

キシメラガトラン 化学構造式
192939-46-1
CAS番号.
192939-46-1
化学名:
キシメラガトラン
别名:
キシメラガトラン;キシメラガトラン (JAN)
英語名:
EXANTA
英語别名:
EXANTA;Exarta;CS-1834;H 376/95;Exanta (TN);XIMELEGATRAN;EXANTA/XIMELEGATRAN;Exanta (XiMelagatran);Ximelagatran [USAN:INN];Ximelagatran (H 376/95)
CBNumber:
CB7838374
化学式:
C24H35N5O5
分子量:
473.57
MOL File:
192939-46-1.mol

キシメラガトラン 物理性質

融点 :
65-68?C
比重(密度) :
1.35±0.1 g/cm3(Predicted)
貯蔵温度 :
-20°C
溶解性:
DMSO : 250 mg/mL (527.91 mM; Need ultrasonic)Methanol : 62.5 mg/mL (131.98 mM; Need ultrasonic)
酸解離定数(Pka):
6.87±0.69(Predicted)
外見 :
色:
白からベージュ
安定性::
Hygroscopic

安全性情報

キシメラガトラン 価格 もっと(8)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TRCX745000 キシメラガトラン
Ximelagatran
192939-46-1 0.5mg ¥22500 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCX745000 キシメラガトラン
Ximelagatran
192939-46-1 1mg ¥34900 2023-06-01 購入
Sigma-Aldrich Japan SML1768 ≥98% (HPLC)
Ximelagatran ≥98% (HPLC)
192939-46-1 5mg ¥33900 2024-03-01 購入
Sigma-Aldrich Japan SML1768 ≥98% (HPLC)
Ximelagatran ≥98% (HPLC)
192939-46-1 25mg ¥137000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TRCX745000 キシメラガトラン
Ximelagatran
192939-46-1 2.5mg ¥68400 2024-03-01 購入

キシメラガトラン 化学特性,用途語,生産方法

効能

抗凝固薬, トロンビン阻害薬

説明

Ximelagatran is an ester prodrug of melagatran, a potent, direct, and reversible thrombin inhibitor (Ki = 1.2 nM). While melagatran has poor oral bioavailability, ximelagatran displays good bioavailability resulting, in part, from rapid absorption at the gastrointestinal tract, as well as rapid onset of action. Ximelagatran is converted to melagatran by reduction and hydrolysis at the liver and other tissues. It is used as an anticoagulant in a variety of situations, including thromboembolic disorders, stroke prevention in atrial fibrillation, and therapy in vein thrombosis.

化学的特性

Off-White Amorphous Solid

定義

ChEBI: A member of the class of azetidines that is melagatran in which the carboxylic acid group has been converted to the corresponding ethyl ester and in which the amidine group has been converted to the corresponding amidoxime. A prodrug for melagatran, ximela atran was the first orally available direct thrombin inhibitor to be brought to market as an anticoagulant, but was withdrawn in 2006 following reports of it causing liver damage.

キシメラガトラン 上流と下流の製品情報

原材料

準備製品


キシメラガトラン 生産企業

Global( 63)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714
fandachem@gmail.com China 9338 55
ATK CHEMICAL COMPANY LIMITED
+undefined-21-51877795
ivan@atkchemical.com China 32760 60
BOC Sciences
+1-631-485-4226
inquiry@bocsci.com United States 19553 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 19892 58
ShenZhen Trendseen Biological Technology Co.,Ltd.
13417589054
trendseenbio@gmail.com China 11681 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501
product@acmec-e.com China 33350 58
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139
orders@jknbiochem.com China 4692 58
Amadis Chemical Company Limited
571-89925085
sales@amadischem.com China 131980 58
Changsha Fuzhen Biotechnology Co.,LTD 0731-13823398 13823398779
313359644@qq.com China 3104 58
Shanghai Boyle Chemical Co., Ltd.
sales@boylechem.com China 2923 55

キシメラガトラン  スペクトルデータ(1HNMR)


192939-46-1(キシメラガトラン)キーワード:


  • 192939-46-1
  • N-[(1R)-1-Cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyamino)iminomethyl]phenyl]methyl]amino]carbonyl]-1-azetidinyl]-2-oxoethyl]glycine Ethyl Ester
  • EXANTA
  • Glycine, N-[(1R)-1-cyclohexyl-2-[(2S)-2-[[[[4-[(hydroxyaMino)iMinoMethyl]phenyl]Methyl]aMino]carbonyl]-1-azetidinyl]-2-oxoethyl]-, ethyl ester
  • Exanta (XiMelagatran)
  • Ethyl 2-[[(1R)-1-Cyclohexyl-2-[(2S)-2-[[4-(N'-Hydroxycarbamimidoyl)Phenyl]Methylcarbamoyl]Azetidin-1-Yl]-2-Oxoethyl]Amino]Acetate Ximelagatran
  • Ethyl 2-[[(1R)-1-Cyclohexyl-2-[(2S)-2-[[4-(N'-Hydroxycarbamimidoyl)Phenyl]Methylcarbamoyl]Azetidin-1-Yl]-2-Oxoethyl]Amino]Acetate Ethyl 2-[[(1R)-1-Cyclohexyl-2-[(2S)-2-[[4-(N'-Hydroxycarbamimidoyl)Phenyl]Methylcarbamoyl]Azetidin-1-Yl]-2-Oxo-Ethyl
  • XIMELEGATRAN
  • EXANTA/XIMELEGATRAN
  • H 376/95
  • CS-1834
  • Exanta (TN)
  • EXANTA; EXARTA; H 376-95; EXANTA (TN); H 376/95; H 37695; XIMELAGATRAN [USAN:INN]; XIMELAGATRAN (JAN/USAN/INN)
  • Exarta
  • Ximelagatran (JAN/USAN/INN)
  • Ximelagatran [USAN:INN]
  • Ximelagatran (H 376/95)
  • Inhibitor,inhibit,Ximelagatran,Thrombin
  • Ethyl ((R)-1-cyclohexyl-2-((S)-2-((4-(N-hydroxycarbamimidoyl)benzyl)carbamoyl)azetidin-1-yl)-2-oxoethyl)glycinate
  • キシメラガトラン
  • キシメラガトラン (JAN)
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