キシラジン

キシラジン 化学構造式
7361-61-7
CAS番号.
7361-61-7
化学名:
キシラジン
别名:
2-[(2,6-ジメチルフェニル)アミノ]-5,6-ジヒドロ-4H-1,3-チアジン;N-(2,6-ジメチルフェニル)-5,6-ジヒドロ-4H-1,3-チアジン-2-アミン;5,6-ジヒドロ-2-(2,6-キシリジノ)-4H-1,3-チアジン;キシラジン;キシラジン標準品
英語名:
Xylazine
英語别名:
Xylazine (free base);2-(2,6-dimethylanilino)-5,6-dihydro-4h-1,3-thiazine;wh7286;Xylazin;bay1470;XYLAZINE;Mobay Rompun;Xylazine, >=99%;Xylazine powder;Xylazine(RoMpun)
CBNumber:
CB8130978
化学式:
C12H16N2S
分子量:
220.33
MOL File:
7361-61-7.mol
MSDS File:
SDS

キシラジン 物理性質

融点 :
140 C
沸点 :
334.2±52.0 °C(Predicted)
比重(密度) :
1.0905 (rough estimate)
屈折率 :
1.5700 (estimate)
貯蔵温度 :
-20°C
溶解性:
50mg/mlでメタノールに可溶。希酸溶液にも可溶。
外見 :
Powder
酸解離定数(Pka):
7.67±0.20(Predicted)
InChI:
InChI=1S/C12H16N2S/c1-9-5-3-6-10(2)11(9)14-12-13-7-4-8-15-12/h3,5-6H,4,7-8H2,1-2H3,(H,13,14)
InChIKey:
BPICBUSOMSTKRF-UHFFFAOYSA-N
SMILES:
S1CCCN=C1NC1=C(C)C=CC=C1C
CAS データベース:
7361-61-7(CAS DataBase Reference)
安全性情報
  • リスクと安全性に関する声明
  • 危険有害性情報のコード(GHS)
主な危険性  T,Xi
Rフレーズ  25-36/37/38
Sフレーズ  45-37/39-26
RIDADR  UN 2811 6.1/PG 3
WGK Germany  3
RTECS 番号 XJ0776300
国連危険物分類  6.1
HSコード  2934990002
毒性 LD50 in mice (mg/kg): 43 i.v.; 121 s.c.; 240 orally; LD50 in rats (mg/kg): 130 orally (Sagner)
絵表示(GHS) GHS hazard pictograms
注意喚起語 危険
危険有害性情報
コード 危険有害性情報 危険有害性クラス 区分 注意喚起語 シンボル P コード
H301 飲み込むと有毒 急性毒性、経口 3 危険 GHS hazard pictograms P264, P270, P301+P310, P321, P330,P405, P501
注意書き

キシラジン 化学特性,用途語,生産方法

効能

鎮痛薬 (獣医薬), α2アドレナリン受容体作動薬

説明

Xylazine is an agonist of α2-adrenergic receptors (Ki = 194 nM). It is an analog of clonidine, an α2-adrenergic receptor agonist used to reduce blood pressure. Xylazine is used for sedation, anesthesia, and analgesia in non-human mammals. This product is also available as an analytical reference standard .

使用

Xylazine is an α2 class of adrenergic receptor agonist. Xylazine is a clonidine analoque that acts on presynaptic and postsynaptic receptors as an a 2-adrenergic agonist.

一般的な説明

Xylazine is soluble in methanol (50 mg/ml), yielding a clear, colorless solution. It is also soluble in dilute HCl acid and in chloroform. Xylazine is practically insoluble in water and in alkali solutions.

作用機序

Xylazine is marketed as its hydrochloride salt as Rompun (100 mg/mL) and Anased (20 mg/mL) injectable solutions for intravenous administration to horses and dogs, respectively. The actions of xylazine may be reversed by the administration of yohimbine, an indolalkylamine alkaloid, that blocks those α2- adrenoreceptors that are stimulated by xylazine.

副作用

High doses of Xylazine can cause dizziness, vomiting, high blood sugar, blurry vision and even overdose deaths. If you inject xylazine into your body, you also may develop skin ulcers and severe wounds that can spread and worsen quickly. Xylazine can lead to depression of the central nervous system along with other adverse effects. As for animals, they may show profound salivation following an injection with xylazine. Other adverse effects for dogs and cats include: muscle tremors, bradycardia with AV-block, hypotension, reduced respiratory rate, movement in response to strong auditory stimuli, and increased urination in cats.

安全性プロファイル

Poison by ingestion, subcutaneous, and intravenous routes. Human systemic effects: change in motor activity, fall in blood pressure, miosis, pleural thickening, pulse rate decrease, somnolence. When heated to decomposition it emits very toxic fumes of NOx and SOx.

キシラジン 上流と下流の製品情報

原材料

準備製品


キシラジン  スペクトルデータ(1HNMR)


7361-61-7(キシラジン)キーワード:


  • 7361-61-7
  • 2-(2,6-dimethylphenylamino)-4h-5,6-dihydro-1,3-thiazine
  • 5,6-dihydro-2-(2,6-xylidino)-4h-1,3-thiazine
  • 5,6-dihydro-2-(2,6-xylidino)-4h-3-thiazine
  • 2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine
  • Xylazine Base & HCL
  • Xylazine,2-(2,6-Dimethylphenylamino)-5,6-dihydro-4H-thiazine hydrochloride
  • Xylazine (200 mg)
  • Xylazine(RoMpun)
  • (5,6-Dihydro-4H-[1,3]thiazin-2-yl)-(2,6-diMethyl-phenyl)-aMine, N-(2,6-DiMethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-aMine
  • Xylazine N-(2,6-Dimethylphenyl)-5,6-dihydro-4H-1,3-thiazin-2-amine
  • Xylazine, >=99%
  • Xylazin
  • bay1470
  • n-(2,6-dimethylphenyl)-5,6-dihydro-4h-3-thiazine-2-amine
  • n-(5,6-dihydro-4h-1,3-thiazinyl)-6-xylidine
  • wh7286
  • N-(2,6-DIMETHYLPHENYL)-5,6-DIHYDRO-4H-1,3-THIAZIN-2-AMINE
  • XYLAZINE
  • 2-[2,6-DIMETHYLPHENYLAMINO]-4H-5,6-DIHYDROTHIAZINE
  • (5,6-DIHYDRO-4H-[1,3]THIAZIN-2-YL)-(2,6-DIMETHYLPHENYL)-AMINE
  • AKOS BBS-00000613
  • XYLAZINE HYDROCHLORIDE A2 ADRENOCEPTOR A GONI
  • XYLAZINE, IMPURITY EN-(2,6-DIMETHYLPHENYL)-S-METHYLDITHIOUREA EP STANDARD
  • XYLAZINE, USP STANDARD
  • XYLAZINE, IMPURITY C2,6-DIMETHYLPHENYL ISOTHIOCYANATE EP STANDARD
  • 4H-1,3-Thiazin-2-amine, N-(2,6-dimethylphenyl)-5,6-dihydro-
  • XYLAZINE HCL/BASE
  • 1,3-THIAZINE,5,6-DIHYDRO-2-(2,6-XYLIDINO)-
  • xylazine free base
  • (5,6-Dihydro-4H-[1,3]thiazin-2-yl)-(2,6-dimethyl-p
  • 2-[(2,6-ジメチルフェニル)アミノ]-5,6-ジヒドロ-4H-1,3-チアジン
  • N-(2,6-ジメチルフェニル)-5,6-ジヒドロ-4H-1,3-チアジン-2-アミン
  • 5,6-ジヒドロ-2-(2,6-キシリジノ)-4H-1,3-チアジン
  • キシラジン
  • キシラジン標準品
  • αアドレナリン作動薬
  • 催眠鎮静薬
  • 抗不安薬
  • 生活関係標準物質
  • 食料品
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