KO143
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- CAS番号.
- 461054-93-3
- 化学名:
- KO143
- 别名:
- KO143;KO143 水和物;tert-ブチル 3-[(2S,5S,8S)-14-メトキシ-2-(2-メチルプロピル)-4,7-ジオキソ-3,6,17-トリアザテトラシクロ[8.7.0.03,8.011,16]ヘプタデカ-1(10),11,13,15-テトラエン-5-イル]プロパノアート;Ko-143;3β-(3-tert-ブトキシ-3-オキソプロピル)-2,3,6,7,12,12aα-ヘキサヒドロ-6β-イソブチル-9-メトキシピラジノ[1′,2′:1,6]ピリド[3,4-b]インドール-1,4-ジオン
- 英語名:
- Ko 143
- 英語别名:
- Ko 143;12aS)-;4-dioxo-;6]pyrido[3;Ko143 ,99%;Pyrazino[1';Ko143 hydrate;KO 143;KO-143;KO143;4-b]indole-3-propanoicacid;12a-octahydro-9-Methoxy-6-(2-Methylpropyl)-1
- CBNumber:
- CB81562442
- 化学式:
- C26H35N3O5
- 分子量:
- 469.57
- MOL File:
- 461054-93-3.mol
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KO143 物理性質
- 融点 :
- 147 ºC
- 沸点 :
- 689.8±55.0 °C(Predicted)
- 比重(密度) :
- 1.24
- 貯蔵温度 :
- Desiccate at -20°C
- 溶解性:
- DMSO:>10mg/mL
- 外見 :
- 粉
- 酸解離定数(Pka):
- 13.31±0.60(Predicted)
- 色:
- ホワイトからオフホワイト
- 安定性::
- 防湿。 DMSO溶液またはエタノール溶液で-20°Cで最大3か月保存できます。
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC3241 |
Ko143
Ko 143 |
461054-93-3 |
1mg |
¥47000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TOC3241 |
Ko143
Ko 143 |
461054-93-3 |
10mg |
¥101000 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01CAY15215 |
Ko 143 |
461054-93-3 |
50mg |
¥233500 |
2024-03-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCK655000 |
KO 143 |
461054-93-3 |
10mg |
¥55300 |
2023-06-01 |
購入 |
富士フイルム和光純薬株式会社(wako)
|
W01TRCK655000 |
KO 143 |
461054-93-3 |
25mg |
¥118500 |
2023-06-01 |
購入 |
KO143 化学特性,用途語,生産方法
説明
Breast cancer resistance protein (BCRP) is an ATP-
binding cassette protein known also as ABCG2. While it normally functions as a high-
capacity urate exporter in the renal system, it also acts as a xenobiotic transporter and contributes to multidrug resistance (
e.g., to mitoxantrone) in certain types of cancer. BCRP is abundant at the intestinal epithelium and blood-
brain barrier, potentially restricting the distribution of certain drugs. Ko 143 is a potent and selective inhibitor of BCRP, preventing the export of mitoxantrone and topotecan in breast cancer cell lines (EC
50s = 23 and 26 nM, respectively). It is much less effective at the transporters P-
glycoprotein and multidrug resistance-
associated protein 1, MRP1. Ko 143 is effective
in vivo in mice.
使用
A potent BCRP (breast cancer resistance protein) inhibitor
生物活性
Potent and selective breast cancer resistance protein multidrug transporter (BCRP) inhibitor (EC 90 = 26 nM). Displays > 200-fold selectivity over P-gp and MRP-1 transporters. Increases intracellular drug accumulation and reverses BCRP-mediated multidrug resistance.
KO143 上流と下流の製品情報
原材料
準備製品
KO143 生産企業
Global( 99)Suppliers
461054-93-3(KO143)キーワード:
- 461054-93-3
- Pyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid, 1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxo-, 1,1-dimethylethyl ester, (3S,6S,12aS)-(Ko143)
- Ko 143
- (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
- 12a-octahydro-9-Methoxy-6-(2-Methylpropyl)-1
- 12aS)-
- 4-b]indole-3-propanoicacid
- 4-dioxo-
- 6]pyrido[3
- Pyrazino[1'
- Ko143 ,99%
- Ko143 hydrate
- tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7, 12,12a-octahydropyrazino[1
- (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-( 2-methylpropyl)-1,4-dioxopyrazino[1′,2′:1,6]pyrido[3,4- b]indole-3-propanoic acid 1,1-dimethylethyl ester hydrate
- tert-butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate
- KO 143;KO-143;KO143
- tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino
- (3S,6S,12aS)-1,2,3,4,6,7,12,12a-Octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2'
- 1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
- (3s,6s,12as)-1,2,3,4,6,7,12,12a-octahydro-9-methoxy-6-(2-methylpropyl)-1,4-dioxopyrazino[1',2':1,6]pyrido[3,4-b]indole-3-propanoic acid 1,1-dimethylethyl ester
- tert-Butyl 3-((3S,6S,12aS)-6-isobutyl-9-methoxy-1,4-dioxo-1,2,3,4,6,7,12,12a-octahydropyrazino[1',2':1,6]pyrido[3,4-b]indol-3-yl)propanoate
- KO143
- KO143 水和物
- tert-ブチル 3-[(2S,5S,8S)-14-メトキシ-2-(2-メチルプロピル)-4,7-ジオキソ-3,6,17-トリアザテトラシクロ[8.7.0.03,8.011,16]ヘプタデカ-1(10),11,13,15-テトラエン-5-イル]プロパノアート
- Ko-143
- 3β-(3-tert-ブトキシ-3-オキソプロピル)-2,3,6,7,12,12aα-ヘキサヒドロ-6β-イソブチル-9-メトキシピラジノ[1′,2′:1,6]ピリド[3,4-b]インドール-1,4-ジオン