iKIX1
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- CAS番号.
- 656222-54-7
- 化学名:
- 别名:
- 英語名:
- iKIX1
- 英語别名:
- iKIX1;2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide;Acetic acid, 2-cyano-, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide;antifungal,Inhibitor,drug-resistant,Fungal,CgGal11A,CgPdr1,infection,C. glabrata,iKIX1,inhibit,iKIX-1,iKIX 1
- CBNumber:
- CB83152630
- 化学式:
- C10H8Cl2N4OS
- 分子量:
- 303.17
- MOL File:
- 656222-54-7.mol
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iKIX1 物理性質
- 比重(密度) :
- 1.551±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- Store at -20°C
- 溶解性:
- DMSO: soluble
- 外見 :
- A crystalline solid
- 酸解離定数(Pka):
- 3.76±0.10(Predicted)
- 色:
- Off-white to light yellow
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
iKIX1 価格
| メーカー |
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製品説明 |
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iKIX1 化学特性,用途語,生産方法
説明
iKIX1 is an inhibitor of interactions between the transcription co-activator Mediator complex and the pleitropic drug resistance (CgPdr1) transcription factor in the pathogen
C. glabrata. It inhibits the interaction between the KIX domain of the Mediator subunit CgGal11A and the activation domain of CgPdr1 (IC
50 = 190.2 μM). iKIX1 (10 and 30 μM) inhibits ketoconazole-induced expression of CgPdr1-target genes involved in multidrug resistance and drug efflux in
C. glabrata. It increases the sensitivity of azole-resistant
C. glabrata strains expressing
CgPDR1 gain-of-function mutations to the antifungal compounds fluconazole and ketoconazole in a concentration-dependent manner. iKIX1 (100 mg/kg) decreases fungal burden in the kidney and spleen in a mouse model of infection with azole-sensitive or -resistant
C. glabrata when administered in combination with low and high doses of fluconazole, respectively.
iKIX1 上流と下流の製品情報
原材料
準備製品
iKIX1 生産企業
Global( 16)Suppliers
- 656222-54-7
- iKIX1
- 2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide
- antifungal,Inhibitor,drug-resistant,Fungal,CgGal11A,CgPdr1,infection,C. glabrata,iKIX1,inhibit,iKIX-1,iKIX 1
- Acetic acid, 2-cyano-, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide