iKIX1
- CAS No.
- 656222-54-7
- Chemical Name:
- iKIX1
- Synonyms
- iKIX1;2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide;Acetic acid, 2-cyano-, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide;antifungal,Inhibitor,drug-resistant,Fungal,CgGal11A,CgPdr1,infection,C. glabrata,iKIX1,inhibit,iKIX-1,iKIX 1
- CBNumber:
- CB83152630
- Molecular Formula:
- C10H8Cl2N4OS
- Molecular Weight:
- 303.17
- MDL Number:
- MFCD00119122
- MOL File:
- 656222-54-7.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P264-P271-P280-P302+P352-P304+P340-P305+P351+P338-P312-P362-P403+P233-P501 | |||||||||
| NFPA 704 |
|
iKIX1 price More Price(10)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 19839 | iKIX1 | 656222-54-7 | 1mg | $50 | 2024-03-01 | Buy |
| Cayman Chemical | 19839 | iKIX1 | 656222-54-7 | 500μg | $28 | 2023-01-06 | Buy |
| Cayman Chemical | 19839 | iKIX1 | 656222-54-7 | 5mg | $238 | 2024-03-01 | Buy |
| Cayman Chemical | 19839 | iKIX1 | 656222-54-7 | 10mg | $450 | 2024-03-01 | Buy |
| ChemScene | CS-0089717 | iKIX1 | 656222-54-7 | 100mg | $650 | 2021-12-16 | Buy |
iKIX1 Chemical Properties,Uses,Production
Description
iKIX1 is an inhibitor of interactions between the transcription co-activator Mediator complex and the pleitropic drug resistance (CgPdr1) transcription factor in the pathogen C. glabrata. It inhibits the interaction between the KIX domain of the Mediator subunit CgGal11A and the activation domain of CgPdr1 (IC50 = 190.2 μM). iKIX1 (10 and 30 μM) inhibits ketoconazole-induced expression of CgPdr1-target genes involved in multidrug resistance and drug efflux in C. glabrata. It increases the sensitivity of azole-resistant C. glabrata strains expressing CgPDR1 gain-of-function mutations to the antifungal compounds fluconazole and ketoconazole in a concentration-dependent manner. iKIX1 (100 mg/kg) decreases fungal burden in the kidney and spleen in a mouse model of infection with azole-sensitive or -resistant C. glabrata when administered in combination with low and high doses of fluconazole, respectively.
iKIX1 Preparation Products And Raw materials
Raw materials
Preparation Products
iKIX1 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9707 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3717 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6870 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |
| Bide Pharmatech Ltd. | 400-1647117 15221909166 | product02@bidepharm.com | China | 63720 | 58 |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6749 | 58 |