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ChemicalBook >> CAS DataBase List >> iKIX1

iKIX1

iKIX1 price.
  • $28 - $650
  • Product name: iKIX1
  • CAS: 656222-54-7
  • MF: C10H8Cl2N4OS
  • MW: 303.17
  • EINECS:
  • MDL Number:MFCD00119122
  • Synonyms:iKIX1;2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide;antifungal,Inhibitor,drug-resistant,Fungal,CgGal11A,CgPdr1,infection,C. glabrata,iKIX1,inhibit,iKIX-1,iKIX 1;Acetic acid, 2-cyano-, 2-[[(3,4-dichlorophenyl)amino]thioxomethyl]hydrazide
Price10 Properties Safety Information Description
10 prices
Selected condition：
Brand
  • AK Scientific
  • Cayman Chemical
  • ChemScene
Package
  • 500μg
  • 1mg
  • 5mg
  • 10mg
  • 25mg
  • 50mg
  • 100mg
  • ManufacturerAK Scientific
  • Product number1523CJ
  • Product description2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide
  • Packaging5mg
  • Price$370
  • Updated2021-12-16
  • Buy
  • ManufacturerCayman Chemical
  • Product number19839
  • Product descriptioniKIX1
  • Packaging500μg
  • Price$28
  • Updated2023-01-06
  • Buy
  • ManufacturerCayman Chemical
  • Product number19839
  • Product descriptioniKIX1
  • Packaging1mg
  • Price$50
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19839
  • Product descriptioniKIX1
  • Packaging5mg
  • Price$238
  • Updated2024-03-01
  • Buy
  • ManufacturerCayman Chemical
  • Product number19839
  • Product descriptioniKIX1
  • Packaging10mg
  • Price$450
  • Updated2024-03-01
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0089717
  • Product descriptioniKIX1
  • Packaging5mg
  • Price$80
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0089717
  • Product descriptioniKIX1
  • Packaging10mg
  • Price$150
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0089717
  • Product descriptioniKIX1
  • Packaging25mg
  • Price$300
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0089717
  • Product descriptioniKIX1
  • Packaging50mg
  • Price$450
  • Updated2021-12-16
  • Buy
  • ManufacturerChemScene
  • Product numberCS-0089717
  • Product descriptioniKIX1
  • Packaging100mg
  • Price$650
  • Updated2021-12-16
  • Buy
Manufacturer Product number Product description Packaging Price Updated Buy
AK Scientific 1523CJ 2-Cyano-N-{[(3,4-dichlorophenyl)carbamothioyl]amino}acetamide 5mg $370 2021-12-16 Buy
Cayman Chemical 19839 iKIX1 500μg $28 2023-01-06 Buy
Cayman Chemical 19839 iKIX1 1mg $50 2024-03-01 Buy
Cayman Chemical 19839 iKIX1 5mg $238 2024-03-01 Buy
Cayman Chemical 19839 iKIX1 10mg $450 2024-03-01 Buy
ChemScene CS-0089717 iKIX1 5mg $80 2021-12-16 Buy
ChemScene CS-0089717 iKIX1 10mg $150 2021-12-16 Buy
ChemScene CS-0089717 iKIX1 25mg $300 2021-12-16 Buy
ChemScene CS-0089717 iKIX1 50mg $450 2021-12-16 Buy
ChemScene CS-0089717 iKIX1 100mg $650 2021-12-16 Buy

Properties

Density :1.551±0.06 g/cm3(Predicted)
storage temp. :Store at -20°C
solubility :DMSO: soluble
form :A crystalline solid
pka :3.76±0.10(Predicted)
color :Off-white to light yellow

Safety Information

Symbol(GHS): GHS hazard pictograms
Signal word: Warning
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning GHS hazard pictograms P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning GHS hazard pictograms P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning GHS hazard pictograms
Precautionary statements:
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P264 Wash hands thoroughly after handling.
P264 Wash skin thouroughly after handling.
P271 Use only outdoors or in a well-ventilated area.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352 IF ON SKIN: wash with plenty of soap and water.
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312 Call a POISON CENTER or doctor/physician if you feel unwell.
P362 Take off contaminated clothing and wash before reuse.
P403+P233 Store in a well-ventilated place. Keep container tightly closed.
P501 Dispose of contents/container to..…

Description

iKIX1 is an inhibitor of interactions between the transcription co-activator Mediator complex and the pleitropic drug resistance (CgPdr1) transcription factor in the pathogen C. glabrata. It inhibits the interaction between the KIX domain of the Mediator subunit CgGal11A and the activation domain of CgPdr1 (IC50 = 190.2 μM). iKIX1 (10 and 30 μM) inhibits ketoconazole-induced expression of CgPdr1-target genes involved in multidrug resistance and drug efflux in C. glabrata. It increases the sensitivity of azole-resistant C. glabrata strains expressing CgPDR1 gain-of-function mutations to the antifungal compounds fluconazole and ketoconazole in a concentration-dependent manner. iKIX1 (100 mg/kg) decreases fungal burden in the kidney and spleen in a mouse model of infection with azole-sensitive or -resistant C. glabrata when administered in combination with low and high doses of fluconazole, respectively.

Suppliers and manufacturers

InvivoChem
TargetMol Chemicals Inc.
Aladdin Scientific Shanghai EFE Biological Technology Co., Ltd. Tianjin Kailiqi Biotechnology Co., Ltd. Shanghai Hongye Biotechnology Co. Ltd ChemeGen(Shanghai) Biotechnology Co.,Ltd. MedBioPharmaceutical Technology Inc Bide Pharmatech Ltd. InvivoChem