THYROID HORMONE RECEPTOR ANTAGONIST, 1-850

251310-57-3

CAS番号.: 251310-57-3

化学名:

别名:

英語名:: THYROID HORMONE RECEPTOR ANTAGONIST, 1-850

英語别名:: TR ANTAGONIST 1-850;THYROID HORMONE RECEPTOR ANTAGONIST, 1-850;1-[[2-[1-(4-nitrophenyl)piperidin-4-ylidene]acetyl]amino]-3-[3-(trifluoromethyl)phenyl]urea;2-(2-(-(4-NITROPHENYL)-4-PIPERIDINYLIDENE)ACETYL)-N-(3-(TRIFLUOROMETHYL) PHENYL)-1-HYDRAZINE CARBOXAMIDE;Acetic acid, 2-[1-(4-nitrophenyl)-4-piperidinylidene]-, 2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide

CBNumber:: CB8468369

化学式:: C21H20F3N5O4

分子量:: 463.41

MOL File:: Mol file

物理性質

安全性情報

用途語

生産企業 14

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 物理性質

比重(密度) :: 1.464±0.06 g/cm3(Predicted)

貯蔵温度 :: Store at -20°C

溶解性:: ≤0.5mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide

外見 :: crystalline solid

酸解離定数(Pka):: 9.75±0.43(Predicted)

安全性情報

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 価格

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THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 化学特性,用途語,生産方法

説明

The activity of the thyroid hormones, L-thyroxine (T4; ) and 3,3'',5-triiodo-L-thyronine (T3; ), is mediated by thyroid hormone nuclear receptors TRα and TRβ. Gene knockout studies in mice indicate that TRα modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TRβ plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary. Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRα and TRβ (IC₅₀s = 1.5 μM), demonstrating ~1,000-fold lower affinity for TRα in intact cells compared with T3. This compound is specific, showing no effect on the activity of the related retinoic acid receptor α.

THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 上流と下流の製品情報

原材料

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THYROID HORMONE RECEPTOR ANTAGONIST, 1-850 生産企業

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251310-57-3
THYROID HORMONE RECEPTOR ANTAGONIST, 1-850
TR ANTAGONIST 1-850
2-(2-(-(4-NITROPHENYL)-4-PIPERIDINYLIDENE)ACETYL)-N-(3-(TRIFLUOROMETHYL) PHENYL)-1-HYDRAZINE CARBOXAMIDE
1-[[2-[1-(4-nitrophenyl)piperidin-4-ylidene]acetyl]amino]-3-[3-(trifluoromethyl)phenyl]urea
Acetic acid, 2-[1-(4-nitrophenyl)-4-piperidinylidene]-, 2-[[[3-(trifluoromethyl)phenyl]amino]carbonyl]hydrazide