갑상선호르몬수용체길항제,1-850
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갑상선호르몬수용체길항제,1-850 속성
- 밀도
- 1.464±0.06 g/cm3(Predicted)
- 저장 조건
- Store at -20°C
- 용해도
- ≤0.5mg/ml in ethanol;50mg/ml in DMSO;50mg/ml in dimethyl formamide
- 물리적 상태
- 결정질 고체
- 산도 계수 (pKa)
- 9.75±0.43(Predicted)
안전
갑상선호르몬수용체길항제,1-850 C화학적 특성, 용도, 생산
개요
The activity of the thyroid hormones, L-thyroxine (T4; ) and 3,3'',5-triiodo-L-thyronine (T3; ), is mediated by thyroid hormone nuclear receptors TRα and TRβ. Gene knockout studies in mice indicate that TRα modulates the effect of thyroid hormone on calorigenesis and on the cardiovascular system, while TRβ plays a role in the development of the auditory system and in the negative feedback of thyroid stimulating hormone by T3 in the pituitary. Thyroid hormone receptor antagonist (1-850) competitively blocks T3 binding to both TRα and TRβ (IC50s = 1.5 μM), demonstrating ~1,000-fold lower affinity for TRα in intact cells compared with T3. This compound is specific, showing no effect on the activity of the related retinoic acid receptor α.갑상선호르몬수용체길항제,1-850 준비 용품 및 원자재
원자재
준비 용품
갑상선호르몬수용체길항제,1-850 공급 업체
글로벌( 14)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| BOC Sciences | 16314854226 |
info@bocsci.com | United States | 9926 | 65 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 |
sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 |
order@med-bio.cn | China | 8141 | 58 |
| Shanghai Universal Biotech Co.,Ltd | 18768175414 |
gaojun@univ-bio.com | China | 24998 | 58 |
| Nanjing Tengyi Biotechnology Co., Ltd | 025-58851786 17714337195 |
sales@tybiochem.com | China | 5586 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 |
customer_service@efebio.com | China | 8739 | 58 |
| Shanghai Lingfei Pharmaceutical Technology Co., Ltd | 15618928656 15618928656 |
771909552@qq.com | China | 1265 | 58 |
| ApexBio Technology | -- |
sales@apexbt.com | United States | 6254 | 58 |