ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN

 化学構造式
CAS番号.
化学名:
别名:
英語名:
ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN
英語别名:
ANTI-CD209;Anti-LSIGN;Anti-CD299;ANTI-CD209L;Anti-HP10347;ANTI-DC-SIGNR;Anti-MGC47866;Anti-DC-SIGN2;Anti-MGC129964;Anti-CD209/CD299
CBNumber:
CB8487575
化学式:
分子量:
0
MOL File:
Mol file

ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN 物理性質

貯蔵温度 :
−70°C
外見 :
凍結乾燥粉末
由来生物:
rabbit

安全性情報

WGK Germany  3

ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN 価格 もっと(1)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
Sigma-Aldrich Japan D2191 clone 120507, purified immunoglobulin, lyophilized powder
Monoclonal Anti-DC-SIGN1 antibody produced in mouse clone 120507, purified immunoglobulin, lyophilized powder
500μG ¥204000 2024-03-01 購入

ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN 化学特性,用途語,生産方法

使用

Monoclonal Anti-DC-SIGN1/DC-SIGN2 antibody produced in mouse is suitable for flow cytometry and immunohistochemistry at a working concentration of 8-25ug/mL using cell or in fixed tissue sections.

一般的な説明

DC-SIGN1 is a type II protein C-type lectin that binds mannose-rich molecules such as ICAM-3 and ICAM-2 in a calcium dependent manner. DC-SIGN1, a 44kDa molecule, is identical to the HIV-1 binding protein. Analysis of various tissues and cell lines suggests that DC-SIGN1 expression is restricted to dendritic cells, although there is evidence of expression in placenta, resting monocytes, and monocytic cell lines. DC-SIGN2 (DC-SIGNR), located on human chromosome 19p13.3, shares 73-80% amino acid identity with DC-SIGN1. DC-SIGN2 is polymorphic and is primarily transcribed in the liver and lymph nodes but not in monocyte-derived DC. Expression of DC-SIGN2 is restricted to endothelial cells derived from liver sinusoids, lymph nodes sinuses, and capillaries. Membrane and soluble forms of the protein have also been found to be expressed in placenta and some monocytic cell lines.

Biochem/physiol Actions

DC-SIGN1 is involved in molecular interactions between dendritic cells and resting T-cells. DC-SIGN interacts with viruses such as X4, R5, X4R5 HIV-1 strains, HIV-2, and SIV. It captures HIV-1 through its interaction with the gp120 envelope glycoprotein and promotes efficient infection of CD4+ T cells that co-express chemokine receptors. DC-SIGN2 also binds mannose residues in a calcium dependent fashion, including ICAM-3 and HIV-1 gp120. It binds to human and simian immunodeficiency viruses and activates infection in trans.

ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN 上流と下流の製品情報

原材料

準備製品


ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN 生産企業

Global( 3)Suppliers
名前 電話番号 電子メール 国籍 製品カタログ 優位度
Riedel-de Haen AG --
United States 6773 87
SIGMA-RBI --
Switzerland 6896 91
R & D Systems --
info@rndsystems.com United States 2195 82

  • MONOCLONAL ANTI-DC-SIGN1
  • MONOCLONAL ANTI-DC-SIGN1/DC-SIGN2
  • MONOCLONAL ANTI-DC-SIGN2
  • ANTI-CD209
  • ANTI-CD209/CD209L
  • ANTI-CD209L
  • ANTI-DC-SIGN/DC-SIGNR (L-SIGN)
  • ANTI-DC-SIGNR
  • ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN
  • ANTI-HUMAN L-SIGN
  • ANTI-HUMAN DC-SIGNR
  • ANTI-HUMAN DC-SIGN2
  • ANTI-HUMAN CD209L
  • Anti-CD209/CD299, Anti-DC-SIGN Related, Anti-DC-SIGN/DC-SIGNR, Anti-Dendritic Cell-Specific ICAM-3 Grabbing Non-Integrin
  • Monoclonal Anti-DC-SIGN1/DC-SIGN2 antibody produced in mouse
  • Anti-CD209L, Anti-DC-SIGNR, Anti-Dendritic Cell-Specific ICAM-3 Grabbing Non-Integrin
  • Monoclonal Anti-DC-SIGN2 antibody produced in mouse
  • Anti-CD209, Anti-Dendritic Cell-Specific ICAM-3 Grabbing Non-Integrin
  • Monoclonal Anti-DC-SIGN1 antibody produced in mouse
  • Anti-C-type lectin domain family 4, member M
  • Anti-HP10347
  • Anti-LSIGN
  • Anti-MGC129964
  • Anti-MGC47866
  • Monoclonal Anti-CLEC4M antibody produced in mouse
  • Anti-CD209/CD299
  • Anti-DC-SIGN Related
  • Anti-DC-SIGN/DC-SIGNR
  • Anti-CD299
  • Anti-CLEC4M antibody produced in rabbit
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