ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN

ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN Struktur
CAS-Nr.
Englisch Name:
ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN
Synonyma:
ANTI-CD209;Anti-LSIGN;Anti-CD299;ANTI-CD209L;Anti-HP10347;ANTI-DC-SIGNR;Anti-MGC47866;Anti-DC-SIGN2;Anti-MGC129964;Anti-CD209/CD299
CBNumber:
CB8487575
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN Eigenschaften

storage temp. 
−70°C
Aggregatzustand
lyophilized powder

Sicherheit

WGK Germany  3

ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Monoclonal Anti-DC-SIGN1/DC-SIGN2 antibody produced in mouse is suitable for flow cytometry and immunohistochemistry at a working concentration of 8-25ug/mL using cell or in fixed tissue sections.

Allgemeine Beschreibung

DC-SIGN1 is a type II protein C-type lectin that binds mannose-rich molecules such as ICAM-3 and ICAM-2 in a calcium dependent manner. DC-SIGN1, a 44kDa molecule, is identical to the HIV-1 binding protein. Analysis of various tissues and cell lines suggests that DC-SIGN1 expression is restricted to dendritic cells, although there is evidence of expression in placenta, resting monocytes, and monocytic cell lines. DC-SIGN2 (DC-SIGNR), located on human chromosome 19p13.3, shares 73-80% amino acid identity with DC-SIGN1. DC-SIGN2 is polymorphic and is primarily transcribed in the liver and lymph nodes but not in monocyte-derived DC. Expression of DC-SIGN2 is restricted to endothelial cells derived from liver sinusoids, lymph nodes sinuses, and capillaries. Membrane and soluble forms of the protein have also been found to be expressed in placenta and some monocytic cell lines.

Biochem/physiol Actions

DC-SIGN1 is involved in molecular interactions between dendritic cells and resting T-cells. DC-SIGN interacts with viruses such as X4, R5, X4R5 HIV-1 strains, HIV-2, and SIV. It captures HIV-1 through its interaction with the gp120 envelope glycoprotein and promotes efficient infection of CD4+ T cells that co-express chemokine receptors. DC-SIGN2 also binds mannose residues in a calcium dependent fashion, including ICAM-3 and HIV-1 gp120. It binds to human and simian immunodeficiency viruses and activates infection in trans.

ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN Anbieter Lieferant Produzent Hersteller Vertrieb Händler.

Global( 3)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Riedel-de Haen AG --
United States 6825 87
SIGMA-RBI --
Switzerland 6913 91
R & D Systems --
info@rndsystems.com United States 2195 82

  • MONOCLONAL ANTI-DC-SIGN1
  • MONOCLONAL ANTI-DC-SIGN1/DC-SIGN2
  • MONOCLONAL ANTI-DC-SIGN2
  • ANTI-CD209
  • ANTI-CD209/CD209L
  • ANTI-CD209L
  • ANTI-DC-SIGN/DC-SIGNR (L-SIGN)
  • ANTI-DC-SIGNR
  • ANTI-DENDRITIC CELL-SPECIFIC ICAM-3 GRABBING NON-INTEGRIN
  • ANTI-HUMAN L-SIGN
  • ANTI-HUMAN DC-SIGNR
  • ANTI-HUMAN DC-SIGN2
  • ANTI-HUMAN CD209L
  • Anti-CD209/CD299, Anti-DC-SIGN Related, Anti-DC-SIGN/DC-SIGNR, Anti-Dendritic Cell-Specific ICAM-3 Grabbing Non-Integrin
  • Monoclonal Anti-DC-SIGN1/DC-SIGN2 antibody produced in mouse
  • Anti-CD209L, Anti-DC-SIGNR, Anti-Dendritic Cell-Specific ICAM-3 Grabbing Non-Integrin
  • Monoclonal Anti-DC-SIGN2 antibody produced in mouse
  • Anti-CD209, Anti-Dendritic Cell-Specific ICAM-3 Grabbing Non-Integrin
  • Monoclonal Anti-DC-SIGN1 antibody produced in mouse
  • Anti-C-type lectin domain family 4, member M
  • Anti-HP10347
  • Anti-LSIGN
  • Anti-MGC129964
  • Anti-MGC47866
  • Monoclonal Anti-CLEC4M antibody produced in mouse
  • Anti-CD209/CD299
  • Anti-DC-SIGN Related
  • Anti-DC-SIGN/DC-SIGNR
  • Anti-CD299
  • Anti-CLEC4M antibody produced in rabbit
  • Anti-DC-SIGN2
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