イソプロピルアミン 化学特性,用途語,生産方法
外観
無色~ほとんど無色, 澄明の液体
溶解性
水, アルコール, エーテルに易溶。水、エタノール及びアセトンに極めて溶けやすい。
解説
2-アミノプロパンともいわれ,n -プロピルアミンの異性体である。化学式 (CH3)2CHNH2 。イソプロピルアミンは,アンモニア臭をもつ無色可燃性の液体で,沸点 34℃。強塩基性を示し,水,アルコール,エーテルによく溶ける。
ブリタニカ国際大百科事典 小項目事典 ブリタニカ
用途
有機合成(和光試薬時報Vol.62 No.3,p.29(1994))。
用途
乳化剤、界面活性剤、医薬農薬原料
用途
医薬?染料中間体,、農薬?界面活性剤原料
説明
Isopropylamine (propan-2-amine, IUPAC) is a colorless, volatile liquid. It is highly flammable, with a flammable range of 2%–10.4% in air. Boiling point is 93°F (33°C), flash point is ?15°F (?26°C), and ignition temperature is 756°F (402°C).
It is miscible with water, with a specific gravity of 0.69, which is lighter than water. Vapor density is 2.04, which is heavier than air. In addition to flammability, isopropylamine is a strong irritant to tissue and has a TLV of 5 ppm in air. The four-digit UN identification number is 1221. The NFPA 704 designation for isopropylamine is health 3, flammability 4, and reactivity 0. Primary uses for isopropylamine are pharmaceuticals, dyes, insecticides, and as a dehairing agent.
化学的特性
Isopropylamine is a colorless, flammable liquid. Isopropylamine is miscible
with water, alcohol, and ether.The odor threshold reportedly ranges from 0.21 to 0.70 ppm;
the pungent, ammoniacal odor becomes irritating at 24mg/m3
(110).
物理的性質
Colorless liquid with a penetrating, ammonia-like odor. Experimentally determined detection and
recognition odor threshold concentrations were 500 μg/m
3 (210 ppb
v) and 1.7 mg/m
3 (700 ppb
v),
respectively (Hellman and Small, 1974). An odor threshold concentration of 25 ppb
v was reported
by Nagata and Takeuchi (1990).
天然物の起源
Not reported found in natu
使用
Isopropylamine is used as a dehairing agentand as an intermediate in the preparation ofmany organics.
調製方法
Isopropylamine can be produced from the corresponding alcohol by reacting with
ammonia in the presence of a dehydrating catalyst, or from the chloride by
reacting with ammonia under pressure. It is also reported that this amine can be
produced from acetone and ammonia or from the acetone oxime (HSDB 1989).
定義
ChEBI: A member of the class of alkylamines that is propane carrying an amino group at position 2.
一般的な説明
A clear colorless liquid with an ammonia-like odor. Flash point -35°F. Boiling point 90°F. Less dense than water Vapors heavier than air. Produces toxic oxides of nitrogen during combustion. Used as a solvent and to make other chemicals.
空気と水の反応
Highly flammable. Water soluble.
反応プロフィール
Isopropylamine is a colorless, alkaline liquid, very volatile, moderately toxic, highly flammable. Dangerous fire hazard when exposed to heat, flame, sparks, or strong oxidizers. When heated to decomposition Isopropylamine emits toxic fumes of oxides of nitrogen [M. K.]. A mixture of Isopropylamine and perchloryl fluoride resulted in an uncontrolled oxidation and/or explosion, [J. Org. Chem., 1980, 45, 4036]. The reaction of 1-chloro-2,3-epoxypropane and the amine and most probably other nitrogen bases, yields a violent exotherm, [Chem. & Ind., 1971, 994].
危険性
Highly flammable, dangerous fire risk.
Strong irritant to tissue.
健康ハザード
Isopropylamine is a strong irritant to theeyes, skin, and respiratory system. A shortexposure to 10–20 ppm can cause irritationof the nose and throat in humans (Procturand Hughes 1978). Prolonged exposure tohigh concentrations may lead to pulmonaryedema. Skin contact can cause dermatitisand skin burns. Exposure to 8000 ppm for4 hours was lethal to rats.
LD50 value, oral (mice): 2200 mg/kg.
化学反応性
Reactivity with Water No reaction; Reactivity with Common Materials: No reactions; Stability During Transport: Stable; Neutralizing Agents for Acids and Caustics: Not pertinent; Polymerization: Not pertinent; Inhibitor of Polymerization: Not pertinent.
工業用途
Isopropylamine can be used as a dehairing agent and as a solvent. It also finds use
as an intermediate in the production of insecticides, herbicides and bactericides
and in the production of pharmaceuticals, dyes and rubber accelerators (HSDB
1989).
環境運命予測
Photolytic. Low et al. (1991) reported that the photooxidation of aqueous primary amine
solutions by UV light in the presence of titanium dioxide resulted in the formation of ammonium
and nitrate ions.
Chemical/Physical. Releases toxic nitrogen oxides when heated to decomposition (Sax and
Lewis, 1987). Forms water-soluble salts with acids.
代謝
One would expect isopropylamine to be readily absorbed from the gut and
respiratory tract. Shorter chain aliphatic amines such as isopropylamine also are
efficiently absorbed through the skin (Beard and Noe 1981). When administered
intravenously, isopropylamine distributed rapidly into tissue compartments with
tissue/plasma ratios ranging from 1.8 in the atrium to 16.7 in the renal medulla
(Privitera et al 1982). During the elimination phase, a half-life of 146 min was
observed in plasma. There do not appear to be any definitive metabolic studies
with this compound, however through a comparison with other substrates, one
might expect oxidation to acetone and ammonia through the action of monoamine
oxidase (Tipton 1980).
イソプロピルアミン 上流と下流の製品情報
原材料
準備製品
ベフノロール
N-T-ブチル-N'-イソプロピルチオ尿素
1,4-ビス(イソプロピルアミノ)アントラキノン
6-エチルチオ-2,4-ビス(イソプロピルアミノ)-1,3,5-トリアジン
カラゾロール
2-メチルチオ-4,6-ビス(イソプロピルアミノ)-1,3,5-トリアジン
1-イソプロピル-4-ピペリドン
(1R,2S,3S,5S)-8-メチル-3-(4-フルオロフェニル)-8-アザビシクロ[3.2.1]オクタン-2-カルボン酸メチル
N-イソプロピルアクリルアミド
オルシプレナリン
N-ISOPROPYLNORTROPINYL A HYDROXYMETHYL)PHENYLACETATE
3-ISOPROPYLAMINO-PROPIONIC ACID ETHYL ESTER X HCL >98%
N-(2-メトキシエチル)メチルアミン
2-エチルアミノ-4-イソプロピルアミノ-6-メチルチオ-1,3,5-トリアジン
ピンドロール
イソシアン酸 プロピル
ニルタミド
1-ISOPROPYL-5-HYDROXYPYRAZOL
2-ブロモニコチンアルデヒド
イソフェンホスメチル標準品
U-47319
ブプロフェジン
3-モルホリン-4-イルプロパン酸
rac-(R*)-α-ホルミルベンゼン酢酸(1β,5β)-8-(1-メチルエチル)-8-アザビシクロ[3.2.1]オクタン-3α-イル
ジイソプロピルアミン
4-(BROMOMETHYL)-N-(L-METHYLETHYL)BENZAMIDE
N-イソプロピルアミドチオりん酸O-メチルO-(4-メチル-2-ニトロフェニル)
アトラジン
2-[エトキシ(イソプロピルアミノ)チオホスフィニルオキシ]安息香酸イソプロピル
3-(3,5-ジクロロフェニル)-N-イソプロピル-2,4-ジオキソ-1-イミダゾリジンカルボアミド
フェナミホス
3-イソプロピル-1H-2,1,3-ベンゾチアジアジン-4(3H)-オン2,2-ジオキシド
4-(4-(Chlorophenyl)imino)-1-isopropyl piperidine
ロルカイニド
クロルプレナリン
N-(4-クロロフェニル)-1-(1-メチルエチル)-4-ピペリジンアミン
3',4'-ジヒドロキシ-α-(イソプロピルアミノ)アセトフェノン