2-[エトキシ(イソプロピルアミノ)チオホスフィニルオキシ]安息香酸イソプロピル 化学特性,用途語,生産方法
外観
無色澄明の液体
溶解性
イソプロパノール, ヘキサン, ジクロロメタン, トルエン>200g/l(20℃)。水:18mg/l(20℃)アセトンに溶け、水にほとんど溶けない。
用途
イソフェンホス試験用標準品。
農薬用途
殺虫剤
使用上の注意
アルゴン封入
化学的特性
Isofenphos is a colorless oil at room temperature. It is sparingly soluble in water, but soluble in cyclohexone, toluene, acetone, and diethyl ether. The US EPA has grouped isofenphos under RUP, which indicates that qualifi ed, certifi ed, and trained workers are required in the safety management of isofenphos. It is used on turf and ornamental trees and shrubs to control white grubs, mole crickets, and other insects, such as soil-dwelling insects, cabbage root fl ies, corn roundworms, and wire worms.
使用
Isofenphos is an organophosphorus insecticide used in soil to control leaf-eating and
soil-dwelling pests in vegetables, fruits, turf and field crops.
一般的な説明
Colorless oil. Non corrosive. Used as an insecticide.
空気と水の反応
Hydrolyzed by alkali solution.
反応プロフィール
Organothiophosphates, such as ISOFENPHOS, are susceptible to formation of highly toxic and flammable phosphine gas in the presence of strong reducing agents such as hydrides. Partial oxidation by oxidizing agents may result in the release of toxic phosphorus oxides.
健康ハザード
Exposures to isofenphos are highly toxic to animals and humans. Acute and prolonged exposures to high concentrations of isofenphos has caused poisoning with symptoms such as increased secretions, diffi culty in breathing, diarrhea, urination, pupil contraction, slowness of the heart, convulsions, and coma. Isofenphos in combination with malathion cause severe poisoning in humans.
環境運命予測
Soil. Rapidly degraded by microbes via oxidative desulfuration in soils forming isofenphos
oxon (Abou-Assaf et al., 1986; Abou-Assaf and Coats, 1987; Somasundarum et al.,
1989), isopropyl salicylate and carbon dioxide (Somasundaram et al., 1989). The formation
of isofenphos oxon is largely dependent upon the pH, moisture and temperature of the
soil. The degradation rate of isofenphos decreased with a decrease in temperature (35°C
>25°C >15°C), moisture content (22.5% >30% >15%) and in acidic and alkaline soils
(pH 6 and 8 >pH 7). After isofenphos was applied to soil at a rate of 1,12 kg/ai/ha, concentrations
of 8.3, 7.2, 5.1 and 1.0 ppm were found after 5, 21, 43 and 69 days, respectively.
Following a second application, 4.9, 1.55, 0.25 and 0.10 ppm of isofenphos were found
after 5, 21, 43 and 69 days, respectively (Abou-Assaf and Coats, 1987).
A pure culture of Arthrobacter sp. was capable of degrading isofenphos at different
soil concentrations (10, 50 and 100 ppm) in less than 6 hours. In previously treated soils,isofenphos could be mineralized to carbon dioxide by indigenous microorganisms (
Plant. Two weeks following application to thatch, 65% of the applied amount was
present (Sears et al., 1987).
Surface Water. In estuarine water, the half-life of isofenphos ranged from 9.8 to 11.9
days (Lacorte et al., 1995).
Photolytic. Irradiation of an isofenphos (500 mg) in hexane and methanol (100 mL)
using a high pressure mercury lamp (l = 254–360 nm) for 24 hours yielded the following
products: isofenphos oxon and O-ethyl hydrogen-N-isopropylphosphoroamidothioa
代謝経路
14C-Isofenphos is bioactivated by mixed-function
oxidases that ultimately give N-desisopropylisofenphos
oxon, a product with 2300-fold greater inhibitory
potency than isofenphos oxon towards housefly head
acetylcholinesterase.271 By housefly and the cuperous
chafer, isofenphos is metabolized to give detoxified
metabolites without the bioactivated N-
desisopropylisofenphos oxon. No difference in kinds of
metabolite is found between the two insects. When
rats are administered 14C-isofenphos, most of the
radioactivity is recovered from the water fraction of the
urine and feces. Aminoisofenphos and isofenphos
oxon are detected in the benzene fraction, and the
other six metabolites are identified as water-soluble
metabolites which include O-ethylhydrogen
phosphoramidate and O-ethylhydrogen
isopropylphosphoramidothioate. Water-soluble
metabolites are predominantly formed through
cleavage of the P-O-aryl linkage.
代謝
Main degradation route
is cleavage of the P?O-aryl ester linkage through
oxidative desulfuration to isofenphos oxon followed by
hydrolysis and oxidative dearylation from isofenphos.
In plant, the major metabolites are salicylic acid and
dihydroxybenzoic acid.
2-[エトキシ(イソプロピルアミノ)チオホスフィニルオキシ]安息香酸イソプロピル 上流と下流の製品情報
原材料
準備製品