MRTX1133
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- CAS番号.
- 2621928-55-8
- 化学名:
- 别名:
- 英語名:
- MRTX1133
- 英語别名:
- MRTX1133;KRAS,Ras,MRTX 1133,G12D,cells,active,wild-type,phosphorylation,mutant,MRTX1133,inactive,ERK,inhibit,tumor,states,MRTX-1133,Inhibitor;4-(4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol;4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-Naphthalenol;2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-;4-[4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2S,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol
- CBNumber:
- CB89021600
- 化学式:
- C33H31F3N6O2
- 分子量:
- 600.63
- MOL File:
- 2621928-55-8.mol
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MRTX1133 物理性質
- 比重(密度) :
- 1.49±0.1 g/cm3(Predicted)
- 溶解性:
- DMSO:50.0(Max Conc. mg/mL);83.24(Max Conc. mM)
- 外見 :
- A solid
- 酸解離定数(Pka):
- 8.05±0.40(Predicted)
- 色:
- Yellow to brown
- InChIKey:
- SCLLZBIBSFTLIN-IFMUVJFISA-N
- SMILES:
- C1=C2C(C(C#C)=C(F)C=C2)=C(C2N=CC3=C(N4CC5NC(CC5)C4)N=C(OC[C@]45C[C@@H](F)CN4CCC5)N=C3C=2F)C=C1O
安全性情報
- リスクと安全性に関する声明
- 危険有害性情報のコード(GHS)
MRTX1133 価格
メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
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MRTX1133 化学特性,用途語,生産方法
説明
MRTX1133 is a potent KRAS
G12D inhibitor. Treatment by intraperitoneal (IP) administration is effective against tumours in xenograft mice with KRAS
G12D mutations. However, MRTX1133 has low oral bioavailability (only 0.5%), which may be related to gastrointestinal malabsorption. In addition, MRTX1133 has two hydrogen bond donors (HBDs): a phenolic group and a secondary amine moiety. And the secondary amine molecule is considered to be the main cause of malabsorption. Currently, an oral prodrug of MRTX1133 has been developed to effectively treat tumours in xenograft mice with the KRAS
G12D mutation
[1].
target
KRas G12D
MRTX1133 上流と下流の製品情報
原材料
準備製品
MRTX1133 生産企業
Global( 86)Suppliers
2621928-55-8()キーワード:
- 2621928-55-8
- 2-Naphthalenol, 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-
- 4-(4-(3,8-Diazabicyclo[3.2.1]octan-3-yl)-8-fluoro-2-(((2R,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl)methoxy)pyrido[4,3-d]pyrimidin-7-yl)-5-ethynyl-6-fluoronaphthalen-2-ol
- MRTX1133
- 4-[4-[(1R,5S)-3,8-diazabicyclo[3.2.1]octan-3-yl]-8-fluoro-2-[[(2S,7aS)-2-fluorohexahydro-1H-pyrrolizin-7a-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoronaphthalen-2-ol
- KRAS,Ras,MRTX 1133,G12D,cells,active,wild-type,phosphorylation,mutant,MRTX1133,inactive,ERK,inhibit,tumor,states,MRTX-1133,Inhibitor
- 4-[4-(3,8-diazabicyclo[3.2.1]oct-3-yl)-8-fluoro-2-[[(2R,7aS)-2-fluorotetrahydro-1H-pyrrolizin-7a(5H)-yl]methoxy]pyrido[4,3-d]pyrimidin-7-yl]-5-ethynyl-6-fluoro-2-Naphthalenol