MRTX1133
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MRTX1133 속성
- 밀도
- 1.49±0.1 g/cm3(Predicted)
- 용해도
- DMSO:50.0(Max Conc. mg/mL);83.24(Max Conc. mM)
- 물리적 상태
- 고체
- 산도 계수 (pKa)
- 8.05±0.40(Predicted)
- 색상
- Yellow to brown
- InChIKey
- SCLLZBIBSFTLIN-IFMUVJFISA-N
- SMILES
- C1=C2C(C(C#C)=C(F)C=C2)=C(C2N=CC3=C(N4CC5NC(CC5)C4)N=C(OC[C@]45C[C@@H](F)CN4CCC5)N=C3C=2F)C=C1O
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
MRTX1133 C화학적 특성, 용도, 생산
개요
MRTX1133 is a potent KRASG12D inhibitor. Treatment by intraperitoneal (IP) administration is effective against tumours in xenograft mice with KRASG12D mutations. However, MRTX1133 has low oral bioavailability (only 0.5%), which may be related to gastrointestinal malabsorption. In addition, MRTX1133 has two hydrogen bond donors (HBDs): a phenolic group and a secondary amine moiety. And the secondary amine molecule is considered to be the main cause of malabsorption. Currently, an oral prodrug of MRTX1133 has been developed to effectively treat tumours in xenograft mice with the KRASG12D mutation[1].target
KRas G12DMRTX1133 준비 용품 및 원자재
원자재
준비 용품
MRTX1133 공급 업체
글로벌( 88)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Hubei Chuchang Biotech Co., Ltd. | +undefined15623860702 |
info@chuchangbiotech.com | China | 111 | 58 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 |
ivan@atkchemical.com | China | 32836 | 60 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 7621 | 58 |
Accela ChemBio Inc. | +1-858-6993322 |
info@accelachem.com | United States | 19479 | 58 |
Nanjing Shizhou Biotechnology Co., Ltd | +86-15850508050 +86-15850508050 |
sean.lv@synzest.com | China | 323 | 58 |
Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 13326 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 |
sales@sarms4muscle.com | China | 10522 | 58 |
LEAP CHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 24738 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 |
sales@chemhifuture.com | China | 3136 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 |
support@targetmol.com | United States | 19973 | 58 |