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ICA 069673

化学構造式
582323-16-8
CAS番号.
582323-16-8
化学名:
别名:
英語名:
ICA 069673
英語别名:
ICA 069673;ICA069673;ICA-069673;ICA-069673 >=98% (HPLC);N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide;N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-;Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
CBNumber:
CB92552603
化学式:
C11H6ClF2N3O
分子量:
269.63
MOL File:
582323-16-8.mol

ICA 069673 物理性質

沸点 :
358.9±37.0 °C(Predicted)
比重(密度) :
1.539±0.06 g/cm3(Predicted)
貯蔵温度 :
Sealed in dry,Room Temperature
溶解性:
DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM)
外見 :
Powder
酸解離定数(Pka):
9.47±0.70(Predicted)

安全性情報

ICA 069673 価格 もっと(2)

メーカー 製品番号 製品説明 CAS番号 包装 価格 更新時間 購入
富士フイルム和光純薬株式会社(wako) W01TOC4305
ICA 069673 		582323-16-8 5mg ￥36000 2024-03-01 購入
富士フイルム和光純薬株式会社(wako) W01TOC4305
ICA 069673 		582323-16-8 25mg ￥136000 2024-03-01 購入

ICA 069673 化学特性,用途語,生産方法

説明

ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.

ICA 069673 上流と下流の製品情報

原材料

準備製品

ICA 069673 生産企業

Global( 59)Suppliers
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ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
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Aladdin Scientific 		+1-+1(833)-552-7181
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Amadis Chemical Company Limited 		571-89925085
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VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
  • 582323-16-8
  • ICA 069673
  • N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
  • ICA069673;ICA-069673
  • Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-
  • ICA-069673 >=98% (HPLC)
  • Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
  • N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide
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