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ICA 069673

CAS No.
582323-16-8
Chemical Name:
ICA 069673
Synonyms
ICA 069673;ICA069673;ICA-069673;ICA-069673 >=98% (HPLC);N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide;N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-;Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
CBNumber:
CB92552603
Molecular Formula:
C11H6ClF2N3O
Molecular Weight:
269.63
MDL Number:
MFCD20926351
MOL File:
582323-16-8.mol
Last updated:2024-07-02 08:55:41

ICA 069673 Properties

Boiling point 358.9±37.0 °C(Predicted)
Density 1.539±0.06 g/cm3(Predicted)
storage temp. Sealed in dry,Room Temperature
solubility DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM)
DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM)
Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM)
form Powder
pka 9.47±0.70(Predicted)
color White to off-white
FDA UNII NCO5DC74G8

ICA 069673 price More Price(30)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 22995 ICA 069673 ≥98% 582323-16-8 5mg $95 2024-03-01 Buy
Cayman Chemical 22995 ICA 069673 ≥98% 582323-16-8 10mg $167 2024-03-01 Buy
Cayman Chemical 22995 ICA 069673 ≥98% 582323-16-8 25mg $363 2024-03-01 Buy
Cayman Chemical 22995 ICA 069673 ≥98% 582323-16-8 50mg $723 2024-03-01 Buy
Tocris 4305 ICA069673 ≥99%(HPLC) 582323-16-8 25 $386 2021-12-16 Buy
Product number Packaging Price Buy
22995 5mg $95 Buy
22995 10mg $167 Buy
22995 25mg $363 Buy
22995 50mg $723 Buy
4305 25 $386 Buy

ICA 069673 Chemical Properties,Uses,Production

Description

ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.

storage

Room temperature

ICA 069673 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 62)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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BOC Sciences
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Career Henan Chemica Co
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InvivoChem
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Aladdin Scientific
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Amadis Chemical Company Limited
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VDM Biochemicals 0330-2528181 sales@vdmbio.com United States 510 64
ICA 069673 N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide ICA069673;ICA-069673 Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro- ICA-069673 >=98% (HPLC) Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide 582323-16-8 C11H6ClF2N3O Selective KCNQ2/Q3 potassium channel opener.