ChemicalBook >> CAS DataBase List >>ICA 069673
ICA 069673
- CAS No.
- 582323-16-8
- Chemical Name:
- ICA 069673
- Synonyms
- ICA 069673;ICA069673;ICA-069673;ICA-069673 >=98% (HPLC);N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide;N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide;Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-;Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
- CBNumber:
- CB92552603
- Molecular Formula:
- C11H6ClF2N3O
- Molecular Weight:
- 269.63
- MDL Number:
- MFCD20926351
- MOL File:
- 582323-16-8.mol
Last updated:2024-07-02 08:55:41
| Boiling point | 358.9±37.0 °C(Predicted) |
|---|---|
| Density | 1.539±0.06 g/cm3(Predicted) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility |
DNF:30.0(Max Conc. mg/mL);111.26(Max Conc. mM) DMSO:36.24(Max Conc. mg/mL);134.4(Max Conc. mM) Ethanol:30.25(Max Conc. mg/mL);112.18(Max Conc. mM) |
| form | Powder |
| pka | 9.47±0.70(Predicted) |
| color | White to off-white |
| FDA UNII | NCO5DC74G8 |
ICA 069673 price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Cayman Chemical | 22995 | ICA 069673 ≥98% | 582323-16-8 | 5mg | $95 | 2024-03-01 | Buy |
| Cayman Chemical | 22995 | ICA 069673 ≥98% | 582323-16-8 | 10mg | $167 | 2024-03-01 | Buy |
| Cayman Chemical | 22995 | ICA 069673 ≥98% | 582323-16-8 | 25mg | $363 | 2024-03-01 | Buy |
| Cayman Chemical | 22995 | ICA 069673 ≥98% | 582323-16-8 | 50mg | $723 | 2024-03-01 | Buy |
| Tocris | 4305 | ICA069673 ≥99%(HPLC) | 582323-16-8 | 25 | $386 | 2021-12-16 | Buy |
ICA 069673 Chemical Properties,Uses,Production
Description
ICA 069673 is a heteromeric Kv7 channel activator. It is selective for Kv7.2/7.3 over Kv7.3/7.5 (EC50s = 0.69 and 14.3 μM, respectively) and also activates Kv7.4, Kv7.5, and heteromeric Kv7.4/7.5 channels in a dose-dependent manner. ICA 069673 has no activity against hERG, Nav1.5, and Kv7.1 cardiac ion channels (IC50s = >30 μM). Oral administration of ICA 069673 increases latency to first tonic-clonic seizure in the rat maximal electroshock and pentylentetrazol-induced seizure models (ED50s = 1.5 and <1 mg/kg, respectively). Formulations containing ICA 069673 are under clinical investigation for the treatment of epilepsy.
storage
Room temperature
ICA 069673 Preparation Products And Raw materials
Raw materials
Preparation Products
Global( 62)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32760 | 60 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30253 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
| VDM Biochemicals | 0330-2528181 | sales@vdmbio.com | United States | 510 | 64 |
| Supplier | Advantage |
|---|---|
| ATK CHEMICAL COMPANY LIMITED | 60 |
| BOC Sciences | 58 |
| Career Henan Chemica Co | 58 |
| InvivoChem | 58 |
| LEAP CHEM CO., LTD. | 58 |
| TargetMol Chemicals Inc. | 58 |
| ShenZhen Trendseen Biological Technology Co.,Ltd. | 58 |
| Aladdin Scientific | 58 |
| Amadis Chemical Company Limited | 58 |
| VDM Biochemicals | 64 |
ICA 069673
N-(2-Chloro-5-pyrimidinyl)-3,4-difluorobenzamide
ICA069673;ICA-069673
Benzamide, N-(2-chloro-5-pyrimidinyl)-3,4-difluoro-
ICA-069673 >=98% (HPLC)
Potassium Channel,ICA 069673,ICA-069673,KcsA,inhibit,Inhibitor
N-(2-Chloropyrimidin-5-yl)-3,4-difluorobenzamide
582323-16-8
C11H6ClF2N3O
Selective KCNQ2/Q3 potassium channel opener.