K-252A

K-252A 価格 もっと(10)

メーカー	製品番号	製品説明	CAS番号	包装	価格	更新時間	購入
富士フイルム和光純薬株式会社(wako)	W01LKTK0021	K252a	99533-80-9	1mg	￥28800	2024-03-01	購入
富士フイルム和光純薬株式会社(wako)	W01LKTK0021	K252a	99533-80-9	100μg	￥18900	2023-06-01	購入
Sigma-Aldrich Japan	K2015	Ready Made Solution, from Nonomuraea longicatena, >98% K-252A Ready Made Solution, from Nonomuraea longicatena, >98%	99533-80-9	200μL	￥34700	2024-03-01	購入
Sigma-Aldrich Japan	K1639	from Nonomuraea longicatena, ≥98% (HPLC) K-252A from Nonomuraea longicatena, ≥98% (HPLC)	99533-80-9	100μg	￥45000	2024-03-01	購入
Sigma-Aldrich Japan	05288	from Nocardiopsis sp. K-252a from Nocardiopsis sp.	99533-80-9	100ug-f	￥43100	2024-03-01	購入

K-252A 化学特性,用途語,生産方法

説明

K252a is a staurosporine analog isolated from Nocardiopsis sp. soil fungi that inhibits protein kinase (PK) C, PKA, Ca²⁺/calmodulin-dependent kinase type II, and phosphorylase kinase with IC₅₀ values of 470, 140, 270, and 1.7 nM, respectively. Because it inhibits neurotrophin receptor tyrosine kinases, K252a at 100-500 nM has been used to suppress trophoblast proliferation and increase apoptosis associated with the disruption of mitochondrial functions in cultured choriocarcinoma cells. Recently, K252a has been shown to inhibit PRK1 (IC₅₀ = 3.2 nM in vitro), a PKC-related kinase that phosphorylates histone H3 at threonine 11 and is involved in androgen-dependent gene expression.

使用

K-252a is used to inhibit protein kinases involved in cell signaling processes, including CaM kinase; phosphorylase kinase, serine/threonine kinases, Trk. It is used to inhibit the actions of nerve growth factor (NGF) on PC1 2 cells and to inhibit smooth muscle myosin light chain kinase .

定義

ChEBI: A organic heterooctacyclic compound that is a potent inhibitor of protein kinase C and is isolated from Nocardiopsis sp K-252a

生物活性

Non-selective protein kinase inhibitor; analog of staurosporine. Inhibits PKC (IC 50 = 32.9 nM), Ca 2+ /calmodulin-stimulated phosphodiesterases (IC 50 = 1.3-2.9 μ M), MLCK (K i = 20 nM) and receptor tyrosine kinases. Inhibits the oncogenic properties of MET; prevents autophosphorylation and activation of downstream effectors (MAPK, Akt).

K-252A 上流と下流の製品情報

原材料

準備製品

K-252A 生産企業

名前	電話番号	電子メール	国籍	製品カタログ	優位度
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
TopScience Biochemical	00852-68527855	info@itopbiochem.com	China Hong Kong	902	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Alfa Chemistry		Info@alfa-chemistry.com	United States	24072	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58
Jilin Chinese Academy of Sciences-yanshen Technology	+undefined18143011203	info@chemextension.com	China	42056	58
Aladdin Scientific	+1-+1(833)-552-7181	sales@aladdinsci.com	United States	57505	58
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15839	69
Chemsky (shanghai) International Co.,Ltd	021-50135380	shchemsky@sina.com	China	15402	60
Dalian Meilun Biotech Co., Ltd.	0411-62910999 13889544652	sales@meilune.com	China	4727	58

99533-80-9(K-252A)キーワード:

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• 99533-80-9
• (9-alpha,10-beta,12-alpha)-este
• [9S,(+)]-2,3,9,10,11,12-Hexahydro-10α-hydroxy-9-methyl-1-oxo-9β,12β-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid methyl ester
• 9,12-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9alpha,10beta,12alpha)-
• 9,1-Epoxy-1H-diindolo(1,2,3-fg:3',2',1'-kl)pyrrolo(3,4-I)(1,6)benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9-alpha,10-beta,12-alpha)-
• (9α,10β,12α)-2,3,9,10,11,12-hexahydro-10-hydroxy-9-Methyl-1-oxo-9,12-epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid Methyl ester
• K 252a(SF 2370)
• 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-0-carboxylicacimethyl
• 9,1-epoxy-1h-diindolo(1,2,3-fg:3’,2’,1’-kl)pyrrolo(3,4-i)(1,6)benzodiazocine-1
• antibiotick252a
• antibioticsf2370
• sf2370
• K-252A, NOCARDIOPSIS SP
• (9S,10R,12R)-2,3,9,10,11,12-HEXAHYDRO-10-HYDROXY-9-METHYL-1-OXO-9,12-EPOXY-1H-DIINDOLO[1,2,3-FG:3',2',1'-KL]PYRROLO[3,4-I][1,6]BENZODIAZOCINE-10-CARBOXYLIC ACID METHYL ESTER
• PROTEIN KINASE INHIBITOR K-252A
• PROTEIN KINASE INHIBITOR FROM NORCARDIOP SIS SP.
• (9S,10R,12R)-2,3,9,10,11,12-Hexahydro-10-hydroxy-9-methyl-1-oxo-9,12-epoxy-1H-diindolo[1.2.3-fg.3'.2'.1'-kl]pyrrolo[3.4-
• PROTEIN KINASE INHIBITOR K-252A FROM NOCARDIOPSIS SP.)
• K-252A
• 9,12-Epoxy-1H-diindolo[1,2,3-fg:3',2',1'-kl]pyrrolo[3,4-i][1,6]benzodiazocine-10-carboxylic acid, 2,3,9,10,11,12-hexahydro-10-hydroxy-9-methyl-1-oxo-, methyl ester, (9S,10R,12R)-
• J61687 Protein Kinase Inhibitor K252A
• PROTEIN KINASE INHIBITOR
• (5S,6R,8R)-Methyl 6-hydroxy-13-oxo-6,7,8,13,14,15-hexahydro-5H-16-oxa-4b,8a,14-triaza-5,8-methanodibenzo[b,h]cycloocta[jkl]cyclopenta[e]-as-indacene-6-carboxylate
• K252a, protein and CAM kinase inhibitor
• (9S)-1-オキソ-9-メチル-10-ヒドロキシ-2,3,9,10,11,12-ヘキサヒドロ-9β,12β-エポキシ-1H-ジインドロ[1,2,3-fg:3',2',1'-kl]ピロロ[3,4-i][1,6]ベンゾジアゾシン-10β-カルボン酸メチル
• (9S)-2,3,9,10,11,12-ヘキサヒドロ-10α-ヒドロキシ-9-メチル-1-オキソ-9β,12β-エポキシ-1H-ジインドロ[1,2,3-fg:3',2',1'-kl]ピロロ[3,4-i][1,6]ベンゾジアゾシン-10-カルボン酸メチル
• 抗生物質K-252a
• 抗生物質SF-2370
• [9S,(+)]-2,3,9,10,11,12-ヘキサヒドロ-10α-ヒドロキシ-9-メチル-1-オキソ-9β,12β-エポキシ-1H-ジインドロ[1,2,3-fg:3',2',1'-kl]ピロロ[3,4-i][1,6]ベンゾジアゾシン-10-カルボン酸メチル
• K-252A
• [9S,(+)]-2,3,9,10,11,12-ヘキサヒドロ-10α-ヒドロキシ-9-メチル-1-オキソ-9β,12β-エポキシ-1H-ジインドロ[1,2,3-fg:3′,2′,1′-kl]ピロロ[3,4-i][1,6]ベンゾジアゾシン-10-カルボン酸メチル
• (9S)-2,3,9,10,11,12-ヘキサヒドロ-10α-ヒドロキシ-9-メチル-1-オキソ-9β,12β-エポキシ-1H-ジインドロ[1,2,3-fg:3′,2′,1′-kl]ピロロ[3,4-i][1,6]ベンゾジアゾシン-10-カルボン酸メチル
• メチル (15S,16R,18R)-16-ヒドロキシ-15-メチル-3-オキソ-28-オキサ-4,14,19-トリアザオクタシクロ[12.11.2.115,18.02,6.07,27.08,13.019,26.020,25]オクタコサ-1(26),2(6),7(27),8(13),9,11,20,22,24-ノナエン-16-カルボキシラート
• (9S)-1-オキソ-9-メチル-10-ヒドロキシ-2,3,9,10,11,12-ヘキサヒドロ-9β,12β-エポキシ-1H-ジインドロ[1,2,3-fg:3′,2′,1′-kl]ピロロ[3,4-i][1,6]ベンゾジアゾシン-10β-カルボン酸メチル
• 蛋白質キナーゼＣ阻害剤
• 抗生物質