アミトラズ 化学特性,用途語,生産方法
外観
白色, 結晶～粉末
溶解性
水に不溶 (～0.1mg/l at 20℃)。多くの有機溶媒に可溶。アセトンに溶け、水にほとんど溶けない。
用途
オクトパミン受容体に作用する剤成虫・幼虫・卵に速効的であり，残効性もある
効能
殺疥癬虫薬, オクトパミン受容体作動薬
農薬用途
ダニ駆除剤
化学的特性
Amitraz forms colorless needle-like crystals.
Liquid formulations may contain flammable organic solvents.
使用
Amitraz is an antiparasitic used to control red spider mites, leaf miners and scale insects. This compound is active by inhibiting the targets monoaminooxidase enzyme.
定義
ChEBI: A tertiary amino compound that is 1,3,5-triazapenta-1,4-diene substituted by a methyl group at position 3 and 2,4-dimethylphenyl groups at positions 1 and 5.
一般的な説明
White monoclinic crystals. Melting point 187-189°F (86-87°C). Insoluble in water. Used as an acaricide, insecticide and treatment of demodectic mange in dogs.
空気と水の反応
Insoluble in water.
反応プロフィール
Unstable in acid.
作用机制
オクトパミン受容体にアゴニストとして作用して，サイクリックアデノシン3′，5′-一リン酸（サイクリックAMP，環状AMP）の過剰産生を引き起こす
农业用途
Insecticde, Acaricide, Veterinary medicine: Registered for control of pear psylla on pears, whitefly and mites on pears and cotton; cattle, dogs, sheep, and
hog dip to control ticks, mange mites, lice and other pests.
Not permitted on apples. Used to control red spider mites,
leaf miners, scale insects, and aphids. Also used on cotton
to control bollworms, white fly, leaf worms, and tobacco
budworms. Not registered for use in EU countries
製品名
AAZDIENO®; ACARAC®; ACADREX®;
ARMY®; AZODIENO®; BAAM®; BOOTS BTS
27419®; BTS 27,419®; BUMETRAN®; COYOTE®;
DANICUT®; ECTODEX®; EDRIZAN®; EDRIZAR®;
GARIAL®; ISTAMBUL®; MITABAN®; MITAC®;
OVASYN®; OVIDREX®; PARSEC®; ROTRAZ®;
SENDER®; TAC-PLUS®; TACTIK®; TRIATIX®;
TRIATOX®; TUDY®; VAPCOZIN TAKTIC®; UPJOHN
U-36059®
薬理学
The mechanism of action of amitraz has not been
completely elucidated, and, presently, a dual mode of
action appearsmost likely. Firstly, the enzymemonoamine
oxidase, which metabolizes neurotransmitter amines in
mites and ticks, is inhibited. Secondly, octopamine
receptors in the central nervous system of ectoparasites
are activated by amitraz, thereby modifying tonic muscle
contractions. The effect of amitraz is to induce increased
neuronal activity, abnormal behavior, detachment, and
death of mites and ticks.
職業ばく露
Those engaged in the manufacture, formulation
and application of this insecticide and acaricide. A
rebuttable presumption against registration for amitraz was
issued on April 6, 1977 by United States Environmental
Protection Agency on the basis of oncogenicity.
Incompatibilities: Keep away from strong oxidizers and
strong acids. Acids may render this material unstable.
代謝経路
14C-Amitraz is applied on lemons grown under
glasshouse conditions at final harvest and the applied
radioactivity is quantitatively recovered, predominantly
in the peel (86%). The total residue at harvest
contains amitraz, N-methyl-N'-(2,4-xylyl)formamidine,
and formyl-2',4'-xylydine and conjugates of 4-amino-
m-toluic acid and the conjugated metabolites which
are convertible to 2,4-xylidine. Amitraz is readily
hydrolyzed at low pH values, forming acid-stable
formyl-2,4-xylydine which can be further hydrolyzed to
2,4-xylidine.
代謝
Amitraz is poorly absorbed when applied topically to
animals. By contrast, orally administered amitraz is
rapidly and extensively absorbed. The metabolism and
excretion of amitraz are also rapid. It is hydrolyzed to
N-(2,4-dimethylphenyl)-N -methyl formamidine and 2,4-
dimethyl formamidine and the final product, 4-amino-3-
methylbenzoic acid, is converted to non-toxic conjugates.
The latter are excreted in the urine and, to a lesser extent,
in bile.
輸送方法
UN2763 Triazine pesticides, solid, toxic, Hazard
Class: 6.1; Labels: 6.1-Poisonous materials.
不和合性
Those engaged in the manufacture, formulation
and application of this insecticide and acaricide. A
rebuttable presumption against registration for amitraz was
issued on April 6, 1977 by United States Environmental
Protection Agency on the basis of oncogenicity.
Incompatibilities: Keep away from strong oxidizers and
strong acids. Acids may render this material unstable.
廃棄物の処理
In accordance with 40CFR
165 recommendations for the disposal of pesticides and
pesticide containers. Must be disposed properly by following
package label directions or by contacting your local or
federal environmental control agency, or by contacting
your regional EPA office.
アミトラズ 上流と下流の製品情報
原材料
準備製品