(S)-2-(4-Fluorophenyl)pyrrolidine
(S)-2-(4-Fluorophenyl)pyrrolidine 物理性質
- 沸点 :
- 235.5±33.0 °C(Predicted)
- 比重(密度) :
- 1.078±0.06 g/cm3(Predicted)
- 貯蔵温度 :
- under inert gas (nitrogen or Argon) at 2–8 °C
- 酸解離定数(Pka):
- 9.76±0.10(Predicted)
- CAS データベース:
- 298690-90-1(CAS DataBase Reference)
(S)-2-(4-Fluorophenyl)pyrrolidine 価格
もっと(7)
| メーカー |
製品番号 |
製品説明 |
CAS番号 |
包装 |
価格 |
更新時間 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC240734 |
(S)-2-(4-Fluorophenyl)pyrrolidine |
298690-90-1 |
250mg |
￥121900 |
2021-03-23 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01FLC240734 |
(S)-2-(4-Fluorophenyl)pyrrolidine |
298690-90-1 |
1g |
￥305000 |
2021-03-23 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-3151 |
(S)-2-(4-Fluorophenyl)pyrrolidine |
298690-90-1 |
250mg |
￥80000 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-3151 |
(S)-2-(4-Fluorophenyl)pyrrolidine |
298690-90-1 |
1g |
￥197500 |
2024-03-01 |
購入 |
|
富士フイルム和光純薬株式会社(wako)
|
W01COBQJ-3151 |
(S)-2-(4-Fluorophenyl)pyrrolidine |
298690-90-1 |
5g |
￥790000 |
2024-03-01 |
購入 |
(S)-2-(4-Fluorophenyl)pyrrolidine 化学特性,用途語,生産方法
使用
(S)-2-(4-Fluorophenyl)pyrrolidine is a pyrrole compound and can be used in the synthesis of organic compounds.
主な応用
(S)-2-(4-Fluorophenyl)pyrrolidine, also known as amide 2-(4-fluorophenyl)-2-pyrrolidinone, is a drug that has been discovered but not yet clinically developed. It is a blocker of the atrial natriuretic peptide receptor.
合成
The mixture of tert-butyl (4-(4-fluorophenyl)-4-oxobutyl)carbamate (0.2 mmol) and trifluoroacetic acid (equiv) in CH2Cl2 was stirred under nitrogen for 3 h. After all the acid and solvent had been removed under vacuum, the obtained substance was transferred to a nitrogen-filled glovebox and dissolved in a mixed solvent of toluene/THF (5:1, 1 mL). Ti(OiPr)4 (0.24 mmol), DABCO (0.04 mmol), Ir-L9 (0.002 mmol) and KI (0.04 mmol) were added subsequently to the above solution. The total solution was made to 3.0 mL. The resulting vial was transferred to an autoclave, which was charged with 50 atm of H2, and stirred at 50 °C for 13 h. The solution was quenched with aqueous sodium bicarbonate solution. The organic phase was concentratedand the metal complex was removed by using a short silica plug to give the (S)-2-(4-Fluorophenyl)pyrrolidine.
(S)-2-(4-Fluorophenyl)pyrrolidine 上流と下流の製品情報
原材料
準備製品
(S)-2-(4-Fluorophenyl)pyrrolidine 生産企業
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298690-90-1()キーワード:
- 298690-90-1
- (2S)-2-(4-fluorophenyl)pyrrolidine
- (S)-2-(4-Fluorophenyl)pyrrolidine (S)-2-(4-Fluorophenyl)pyrrolidine
- (S)-2-(4-Fluorophenyl)pyrrolidine
- Pyrrolidine, 2-(4-fluorophenyl)-, (2S)-