(S)-2-(4-플루오로페닐)피롤리딘
|
|
(S)-2-(4-플루오로페닐)피롤리딘 속성
- 끓는 점
- 235.5±33.0 °C(Predicted)
- 밀도
- 1.078±0.06 g/cm3(Predicted)
- 저장 조건
- under inert gas (nitrogen or Argon) at 2–8 °C
- 산도 계수 (pKa)
- 9.76±0.10(Predicted)
- CAS 데이터베이스
- 298690-90-1(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
| HS 번호 | 2933998090 |
|---|
| 그림문자(GHS): |
|
||||||||||||||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 신호 어: | Warning | ||||||||||||||||||||||||||||
| 유해·위험 문구: |
|
||||||||||||||||||||||||||||
| 예방조치문구: |
|
(S)-2-(4-플루오로페닐)피롤리딘 C화학적 특성, 용도, 생산
용도
(S)-2-(4-Fluorophenyl)pyrrolidine is a pyrrole compound and can be used in the synthesis of organic compounds.주요 응용
(S)-2-(4-Fluorophenyl)pyrrolidine, also known as amide 2-(4-fluorophenyl)-2-pyrrolidinone, is a drug that has been discovered but not yet clinically developed. It is a blocker of the atrial natriuretic peptide receptor.Synthesis
The mixture of tert-butyl (4-(4-fluorophenyl)-4-oxobutyl)carbamate (0.2 mmol) and trifluoroacetic acid (equiv) in CH2Cl2 was stirred under nitrogen for 3 h. After all the acid and solvent had been removed under vacuum, the obtained substance was transferred to a nitrogen-filled glovebox and dissolved in a mixed solvent of toluene/THF (5:1, 1 mL). Ti(OiPr)4 (0.24 mmol), DABCO (0.04 mmol), Ir-L9 (0.002 mmol) and KI (0.04 mmol) were added subsequently to the above solution. The total solution was made to 3.0 mL. The resulting vial was transferred to an autoclave, which was charged with 50 atm of H2, and stirred at 50 °C for 13 h. The solution was quenched with aqueous sodium bicarbonate solution. The organic phase was concentratedand the metal complex was removed by using a short silica plug to give the (S)-2-(4-Fluorophenyl)pyrrolidine.(S)-2-(4-플루오로페닐)피롤리딘 준비 용품 및 원자재
원자재
준비 용품
(S)-2-(4-플루오로페닐)피롤리딘 공급 업체
글로벌( 69)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| Tianjin Xinghan Biotechnology Co., Ltd | +8618698089028 |
1725517238@qq.com | China | 2479 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
| Guangzhou Yuheng Pharmaceutical Technology Co., Ltd | +8613580539051 |
joe@yuhengpharm.com | CHINA | 21149 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 |
sale04@alfachem.cn | China | 13326 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 |
laboratory@coreychem.com | China | 30250 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 |
info@dycnchem.com | China | 52861 | 58 |
| Hangzhou Huarong Pharm Co., Ltd. | 571-86758373 +8613588754946 |
sales@huarongpharm.com | CHINA | 3149 | 58 |
| Golden Pharma Co., Limited | +undefined18958062155 |
sales@zjgoldpharm.com | China | 5905 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 |
info@gihichemicals.com | China | 50003 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43348 | 58 |
(S)-2-(4-플루오로페닐)피롤리딘 관련 검색:
폴리비닐피로리돈 2-피로리딘온,1-에테닐- 포비돈요오드 피롤리딘 N-메틸-2-피롤리디논
METHYL-2-PYRROLIDONE
2-(3-Fluorophenyl)-pyrrolidine
(3S,4R)-4-(2-FLUOROPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID
2-(2-FLUOROPHENYL)PYRROLIDINE
2-(2,4-DIFLUORO-PHENYL)-PYRROLIDINE
(R)-2-(3-Fluorophenyl)pyrrolidine
3-(3-FLUOROPHENYL)PYRROLIDINE
(S)-2-(3-Fluorophenyl)pyrrolidine
(3S,4R)-4-(3-FLUOROPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID
(3S,4R)-4-(4-FLUOROPHENYL)PYRROLIDINE-3-CARBOXYLIC ACID
((3R,4S)-4-(3-FLUOROPHENYL)PYRROLIDIN-3-YL)METHANOL
3-(4-FLUORO-PHENYL)-PYRROLIDINE
(R)-2-(4-Fluorophenyl)pyrrolidine