8-(3-クロロスチリル)カフェイン

8-(3-クロロスチリル)カフェイン 化学特性,用途語,生産方法

説明

8-(3-Chlorostyryl)caffeine (CSC) is an adenosine A₂ receptor antagonist (K_i = 54 nM). It is selective for adenosine A₂ over A₁ receptors (K_i = 28 μM). CSC reverses locomotor depression induced by the adenosine A_2A agonist APEC in mice (ED₅₀ = 16 μg/kg, i.p.). It increases locomotion in mice when administered at a dose of 5 mg/kg. CSC (5 mg/kg) reverses the shortening of the rotational motor response and increases in striatal adenosine A₂ receptor levels induced by L-DOPA in a rat model of Parkinson’s disease induced by 6-OHDA . It also inhibits monoamine oxidase B (MAO-B; K_i = 100 nM) and reduces MAO-B activity in brain mitochondrial preparations from wild-type and A_2A^-/- mice.

使用

8-(3-Chlorostyryl)caffeine is a selective Adenosine A2A-R and MAO-B inhibitor.

定義

ChEBI: 8-(3-chlorostyryl)caffeine is caffeine substituted at its 8-position by an (E)-3-chlorostyryl group. It has a role as an adenosine A2A receptor antagonist and an EC 1.4.3.4 (monoamine oxidase) inhibitor. It is a trimethylxanthine and a member of monochlorobenzenes. It is functionally related to a caffeine.

8-(3-クロロスチリル)カフェイン 上流と下流の製品情報

原材料

準備製品

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• 147700-11-6
• 8-(3-CHLOROSTYRYL) CAFFEINE A2A ADENOSIN E RECEPTO
• 1,3,7-Trimethyl-8-(3-chlorostyryl)xanthine, CSC
• 1H-Purine-2,6-dione,8-[(1E)-2-(3-chlorophenyl)ethenyl]-3,7-dihydro-1,3,7-triMethyl-
• 8-[2-(3-Chloro-phenyl)-vinyl]-1,3,7-trimethyl-3,7-dihydro-purine-2,6-dione
• (E)-8-[2-(3-Chlorophenyl)ethenyl]-3,7-dihydro-1,3,7-trimethyl-1H-purine-2,6-dione
• (E)-8-(3-Chlorostyryl)caffeine
• 8-(3-クロロスチリル)カフェイン