라파퀴스타트

라파퀴스타트
라파퀴스타트 구조식 이미지
카스 번호:
189060-13-7
한글명:
라파퀴스타트
동의어(한글):
라파퀴스타트
상품명:
LAPAQUISTAT
동의어(영문):
TAK-475;CS-1400;LAPAQUISTAT;Lapaquistat Acetate;Lapaquistat Acetate (TAK-475);Lapaquistat and Lapaquistat Acetate;1-[[(3R,5S)-1-[3-(Acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-4-piperidineacetic acid;2-[1-[2-[1-(3-Acetoxy-2,2-diMethylpropyl)-7-chloro-5(S)-(2,3-diMethoxyphenyl)-2-oxo-1,2,3,5-tetrahydro-4,1-benzoxazepin-3(R)-yl]acetyl]piperidin-4-yl]acetic acid;4-Piperidineacetic acid, 1-[2-[(3R,5S)-1-[3-(acetyloxy)-2,2-dimethylpropyl]-7-chloro-5-(2,3-dimethoxyphenyl)-1,2,3,5-tetrahydro-2-oxo-4,1-benzoxazepin-3-yl]acetyl]-;2-(1-(2-((3R,5S)-1-(3-Acetoxy-2,2-dimethylpropyl)-7-chloro-5-(2,3-dimethoxyphenyl)-2-oxo-1,2,3,5-tetrahydrobenzo[e][1,4]oxazepin-3-yl)acetyl)piperidin-4-yl)acetic acid
CBNumber:
CB01509119
분자식:
C33H41ClN2O9
포뮬러 무게:
645.14
MOL 파일:
189060-13-7.mol
MSDS 파일:
SDS

라파퀴스타트 속성

녹는점
194-196℃
끓는 점
826.4±65.0 °C(Predicted)
밀도
1.246±0.06 g/cm3(Predicted)
저장 조건
Store at -20°C
용해도
클로로포름(약간 용해됨), DMSO(약간 용해됨), 메탄올(약간 용해됨)
물리적 상태
고체
물리적 상태
단단한 모양
산도 계수 (pKa)
4.66±0.10(Predicted)
색상
하얀색

안전

라파퀴스타트 C화학적 특성, 용도, 생산

용도

A novel squalene synthase inhibitor. Lapaquistat acetate decreased plasma cholesterol and triglyceride levels, by lowering lipoproteins containing apoB100. Treatment with Lapaquistat acetate increased collagen concentration and transformed coronary plaques into fibromuscular plaques. Lapaquistat acetate also suppressed the expression of matrix metalloproteinase-1 and plasminogen activator inhibitor-1 in the plaque and increased peripheral coenzyme Q10 levels.Antiarteriosclerotics.

라파퀴스타트 준비 용품 및 원자재

원자재

준비 용품


라파퀴스타트 공급 업체

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SPIRO PHARMA
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Nanjing NingFan Pharm-Tech CO. LTD. 17368696818
China 1986 58

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