Butorphanol (tartrate) (Item No. 23812) is an analytical reference material categorized as an opioid. Butorphanol is regulated as a Schedule IV compound in the United States. This product is intended for research and forensic applications.
용도
Analgesic;
antitussive.
정의
ChEBI: The (S,S)-tartaric acid salt of butorphanol. It is used for relief or moderate to severe pain.
Mechanism of action
Butorphanol is a strong agonist at κ opioid receptors, and through this interaction, it is five times
more potent than morphine as an analgesic. The κagonists have a lower ceiling analgesic effect
than full μ agonists; thus, they are not as effective in treating severe pain. Butorphanol is an
antagonist at μ opioid receptors with approximately one-sixth the potency of naloxone. If given to a
person addicted to a μ agonist, butorphanol will induce an immediate onset of abstinence
syndrome.
부작용
Butorphanol has a different spectrum of side effects than μ opioid analgesics. Respiratory
depression occurs. There is a lower ceiling on this effect, however, and it is not generally lethal,
as is the case with high doses of μ agonists. Major side effects after normal analgesic doses are
sedation, nausea, and sweating, as well as dysphoric (hallucinogenic) effects at higher doses.
Butorphanol causes an increase in pulmonary arterial pressure and pulmonary vascular resistance.
There is an overall increased workload on the heart, and it should not be used in patients with
congestive heart failure or to treat pain from acute myocardial infarction. Butorphanol has low abuse potential and is not a scheduled drug.
