1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE
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1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 속성
- 끓는 점
- 207.5±23.0 °C(Predicted)
- 밀도
- 0.946±0.06 g/cm3(Predicted)
- 저장 조건
- Inert atmosphere, 2-8°C
- InChI
- InChI=1S/C9H13Cl/c1-9(2,3)7-5-4-6-8-10/h4,6H,8H2,1-3H3/b6-4+
- InChIKey
- ZIXABMZBMHDFEZ-GQCTYLIASA-N
- SMILES
- C(Cl)/C=C/C#CC(C)(C)C
- CAS 데이터베이스
- 287471-30-1(CAS DataBase Reference)
안전
1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE C화학적 특성, 용도, 생산
개요
1-Chloro-6,6-dimethyl-2-hepten-4-yne is the allylamine antifungal agents terbinafine intermediate.1-Chloro-6,6-dimethyl-2-hepten-4-yne choose to inhibit COX-fungal squalene, so that reduction of membrane ergosterol, thus inhibiting the growth of fungi play an inhibitory role; right ergosterol synthesis of precursors and no inhibitory effect on other stages.용도
1-Chloro-6,6-dimethyl-2-heptene-4-yne is a hydrocarbon derivative and can be used as a pharmaceutical intermediate.주요 응용
1-Chloro-6,6-dimethyl-2-hepten-4-yne is a chlorinating agent that has been used to minimise hydrochloric acid by converting it to chloride. It is also used in the chlorination of magnesium and other metals. 1-Chloro-6,6-dimethyl-2-hepten-4-yne has been shown to be an effective antifungal agent against dermatophytes such as Trichophyton rubrum and Microsporum canis. The compound is toxic to humans and animals because it produces acrolein and terbinafine during chlorination. It also produces hydrochloric acid as a by-product of chlorination.Synthesis
1-Chloro-6,6-dimethyl-2-hepten-4-yne mainly due to keratin aggregation produce squalene, was squalene cyclooxygenase inhibition, squalene in the cells of a large number gathered in the form of lipid droplets penetrate fungal cell membrane, destruction of the membrane lipid composition, resulting in fungal death. A typical procedure for preparing of 1-chloro-6,6-dimethyl-2-hepten-4-yne using boron trichloride is as follows: Compound 1 (53 g, 0.38 mol) in 2800 mL of n-hexane was cooled to 10??15??. Boron trichloride (1 M in hexane, 480 mL, 0.48 mol) was added to the mixture at 15??20?? over a 10 min period. After 10 min of stirring at 20??, the mixture was quenched with 1000 mL of water and stirred for 10 min. The separated organic phase was washed with 20% NaCl, dried (MgSO4), and evaporated to afford the title compound 2 (57.1 g, 95%) in 9:1 E:Z ratio.1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 준비 용품 및 원자재
원자재
준비 용품
1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 공급 업체
글로벌( 166)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
shandong perfect biotechnology co.ltd | +86-53169958659; +8618596095638 |
sales@sdperfect.com | China | 294 | 58 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 |
info@dakenam.com | China | 18628 | 58 |
Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 |
fandachem@gmail.com | China | 9284 | 55 |
Shanghai Yingrui Biopharma Co., Ltd. | +86-21-33585366 - 03@ |
sales03@shyrchem.com | CHINA | 738 | 60 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29888 | 58 |
Xi'an Kono chem co., Ltd., | 029-86107037 13289246953 |
info@konochemical.com | China | 2995 | 58 |
Chongqing Chemdad Co., Ltd | +86-023-6139-8061 +86-86-13650506873 |
sales@chemdad.com | China | 39916 | 58 |
Shanghai Yingrui Biopharma Co.,Ltd | 21-33585366 |
export01@shyrchem.com | CHINA | 1320 | 58 |
CONIER CHEM AND PHARMA LIMITED | +8618523575427 |
sales@conier.com | China | 49392 | 58 |
SIMAGCHEM CORP | +86-13806087780 |
sale@simagchem.com | China | 17367 | 58 |
1-CHLORO-6,6-DIMETHYL-2-HEPTEN-4-YNE 관련 검색:
Terbinafine Hydrochloride
6,6-Dimethyl-1-hepten-4-yn-3-ol
1-CHLORO-6,6-DIMETHYL-2-HEPTENE-4-YNE
3,3-Dimethyl-1-butyne
N-Methyl-2-naphthaMide
1-Methyl-aminomethyl naphthalene
(Z)-N,6,6-triMethyl-N-(naphthalen-1-ylMethyl)hept-2-en-4-yn-1-aMine
1-Chloro-6,6-dimethyl-2-heptene-4-yne
(E)-N,6,6-triMethyl-N-(naphthalen-2-ylMethyl)hept-2-en-4-yn-1-aMine
Terbinafine
methyl-(naphthalen-2-ylmethyl)azanium
N-[(2E)-6,6-DiMethyl-2-hepten-4-yn-1-yl]-N-Methyl-2-naphthaleneMethanaMine Hydrochloride
cis-Terbinafine Hydrochloride
(E)-1-Bromo-6,6-dimethyl-2-hepten-4-yne
Chlorotrimethylsilane
chlorempenthrin