(S)-MEPHENYTOIN
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(S)-MEPHENYTOIN 속성
- 녹는점
- 135-138 °C
- 끓는 점
- 358.94°C (rough estimate)
- 밀도
- 1.154±0.06 g/cm3 (20 ºC 760 Torr)
- 굴절률
- 1.6660 (estimate)
- 저장 조건
- 2-8°C
- 용해도
- DMSO(약간 용해됨), 에탄올(약간 용해됨), 메탄올(약간 용해됨)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- pKa 8.1 (Uncertain)
- 색상
- 회백색
- CAS 데이터베이스
- 50-12-4(CAS DataBase Reference)
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
위험품 표기 | Xn | ||
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위험 카페고리 넘버 | 22-36/37/38 | ||
안전지침서 | 26-36 | ||
WGK 독일 | 2 | ||
HS 번호 | 2933210000 | ||
유해 물질 데이터 | 50-12-4(Hazardous Substances Data) | ||
독성 | LD50 i.p. in mice: 300 mg/kg (Dzhagatspanyan) |
그림문자(GHS): |
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신호 어: | Warning | |||||||||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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(S)-MEPHENYTOIN C화학적 특성, 용도, 생산
개요
Mephenytoin is N-methylated at position 3 with an ethyl group replacing one of the phenyl substituents at position 5. It is indicated for focal and jacksonian seizures in patients refractory to less toxic AEDs. Mephenytoin produces more sedation than phenytoin and should be used only when safer drugs have failed, because it is associated with an increased incidence of serious toxicities, such as severe rash, agranulocytosis, and hepatitis. Its N-desmethyl metabolite, 5-phenyl- 5-ethylhydantoin, contributes to both efficacy and toxicity for mephenytoin. The drug is no longer commercially available inside but is still available outside the United States.용도
Anticonvulsant.생물학적 활성
CYP2C19 substrate. Anticonvulsant.부작용
Side effects, including rash, fever, and fatal blood dyscrasia, prevent the use as an anticonvulsant drug of first choice.Safety Profile
Poison by ingestion and intraperitoneal routes. Human systemic effects by ingestion: somnolence, hemorrhage, changes in teeth and supporting structures. Human mutation data reported. An experimental teratogen. An FDA proprietary drug used as an anticonvulsant. When heated to decomposition it emits toxic fumes of NOx.(S)-MEPHENYTOIN 준비 용품 및 원자재
원자재
Cyanide, Quant Test Strips
Dilute hydrochloric acid
프로피오페논
사이안화 칼륨
암모늄 카보네이트
중아황산나트륨
나트륨
메포바르비탈
1-(1-cyano-1-phenylpropyl)-3-methylurea
2,4-이미다졸리딘디온,5-에틸-5-페닐-,(+-)-
메틸아민
모노메틸유레아
요오드 메탄
N,N-디메틸포름아마이드 디메틸 아세탈
준비 용품
(S)-MEPHENYTOIN 공급 업체
글로벌( 103)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
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TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 |
marketing@targetmol.com | United States | 32161 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 |
sales@invivochem.cn | United States | 6391 | 58 |
Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 |
sales@chemhifuture.com | China | 3135 | 58 |
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 |
Mandy@hangyubiotech.com | China | 10986 | 58 |
Mainchem Co., Ltd. | +86-0592-6210733 |
sale@mainchem.com | China | 32343 | 55 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 |
3bsc@sina.com | China | 15839 | 69 |
WUHAN SUN-SHINE BIO-TECHNOLOGY Co., Ltd. | 17702719238 17702719238 |
sales@sun-shinechem.com | China | 985 | 64 |
China DongFan Chemical Co.,LTD | 86-0571-85151182 |
China | 5691 | 66 | |
Sinopharm Chemical Reagent Co,Ltd. | 86-21-63210123 |
sj_scrc@sinopharm.com | China | 9815 | 79 |
Beijing HuaMeiHuLiBiological Chemical | 010-56205725 |
waley188@sohu.com | China | 12335 | 58 |
(S)-MEPHENYTOIN 관련 검색:
Voriconazole
4-HYDROXY MEPHENYTOIN,4-HYDROXY MEPHENYTOIN
(R)-1-METHYLMEPHENYTOIN
(S)-MEPHENYTOIN
(S)-Mephenytoin
(R)-(-)-MEPHENYTOIN,(R)-MEPHENYTOIN,(R)-(-)-MEPHENYTOIN,(R)-MEPHENYTOIN
5-Phenylhydantoin
4-HYDROXY MEPHENYTOIN-D3,4-HYDROXY MEPHENYTOIN-D3
RAC MEPHENYTOIN-D3,RAC MEPHENYTOIN-D3
(+/-)-N-3-Benzylnirvanol
DESMETHYL MEPHENYTOIN,DESMETHYL MEPHENYTOIN
N-DESMETHYL MEPHENYTOIN-D5,N-DESMETHYL MEPHENYTOIN-D5
(S)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN=(S)-MEPHENYTOIN,(S)-5-ETHYL-3-METHYL-5-PHENYLHYDANTOIN=(S)-MEPHENYTOIN
(+/-)-4'-METHOXYMEPHENYTOIN
S-[4-14C]MEPHENYTOIN,S-[4-14C]MEPHENYTOIN
(4-ETHYL-2,5-DIOXO-4-PHENYLIMIDAZOLIDIN-1-YL)ACETIC ACID
(2,5-DIOXO-3',4'-DIHYDRO-1H,2'H-SPIRO[IMIDAZOLIDINE-4,1'-NAPHTHALEN]-1-YL)ACETIC ACID
(2,5-DIOXO-2',3'-DIHYDRO-1H-SPIRO[IMIDAZOLIDINE-4,1'-INDEN]-1-YL)ACETIC ACID