ChemicalBook >제품 카탈로그 >생화학 공학>억제제>프로테아제>감마 - 세크리 테아 제 억제제>cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid 구조식 이미지

카스 번호:: 471905-41-6

상품명:: cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid

동의어(영문):: CS-10;MK-0752/MK0752;MK-0752, >=98%;MK-0752, 10 mM in DMSO;cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid;3-(cis-4-((4-Chlorophenyl)sulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;3-((1r,4s)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanoic acid;Cyclohexanepropanoic acid, 4-[(4-chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)-, cis-;cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid MK-0752;Aβ40,MK 0752,inhibit,barrier,γ-secretase,blood-brain,Inhibitor,MK-0752,CNS,MK0752,Gamma secretase

CBNumber:: CB02521129

분자식:: C21H21ClF2O4S

포뮬러 무게:: 442.9

MOL 파일:: 471905-41-6.mol

속성

안전

용도

공급 업체 98

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid 속성

녹는점: 166.6-167.5 °C(Solv: isopropyl acetate (108-21-4); heptane (142-82-5))

끓는 점: 616.9±55.0 °C(Predicted)

밀도: 1.361

저장 조건: Store at -20°C

용해도: ≥22.15 mg/mL in DMSO; insoluble in H2O; ≥48.8 mg/mL in EtOH with ultrasonic

물리적 상태: 가루

산도 계수 (pKa): 4.76±0.10(Predicted)

색상: White to off-white

안전

위험 및 안전 성명
위험 및 사전주의 사항 (GHS)

HS 번호	29163990

그림문자(GHS):

신호 어:

Warning

유해·위험 문구:

암호	유해·위험 문구	위험 등급	범주	신호 어	그림 문자	P- 코드
H317	알레르기성 피부 반응을 일으킬 수 있음	피부 과민성 물질	구분 1	경고		P261, P272, P280, P302+P352,P333+P313, P321, P363, P501

예방조치문구:

P261	분진·흄·가스·미스트·증기·...·스프레이의 흡입을 피하시오.
P272	작업장 밖으로 오염된 의복을 반출하지 마시오.
P280	보호장갑/보호의/보안경/안면보호구를 착용하시오.
P302+P352	피부에 묻으면 다량의 물로 씻으시오.
P333+P313	피부자극성 또는 홍반이 나타나면 의학적인 조치·조언를 구하시오.
P501	...에 내용물 / 용기를 폐기 하시오.

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid C화학적 특성, 용도, 생산

용도

γ-Secretase is a protease complex that cleaves single-pass transmembrane proteins, such as Notch receptors and β-amyloid precursor protein (APP), within the transmembrane domain. MK-0752 is a potent, reversible inhibitor of γ-secretase, reducing the cleavage of APP to Aβ40 in human neuroblastoma SH-SY5Y cells with an IC50 value of 5 nM. It is orally bioavailable and crosses the blood-brain barrier, as orally administered MK-0752 dose-dependently reduces the generation of new amyloid β protein in the brain of rhesus monkeys. Through its effects on the Notch pathway, MK-0752 reduces the number of breast cancer stem cells in tumorgrafts, enhancing the efficacy of the chemotherapy drug docetaxel in mice with breast cancer tumors.[Cayman Chemical]

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid 준비 용품 및 원자재

원자재

3-((1s,4r)-4-(4-chlorophenylsulfonyl)-4-(2,5-difluorophenyl)cyclohexyl)propanal 2-(1-(4-클로로페닐술포닐)비닐)-1,4-디플루오로벤젠 2-((4-클로로페닐술포닐)메틸)-1,4-디플루오로벤젠 2,5-Difluorobenzyl bromide 4-(4-클로로페닐술포닐)-4-(2,5-디플루오로페닐)시클로헥사논 (4-클로로페닐)(2,5-디플루오로벤질)술판 4-Chlorothiophenol 설파믹산 아염소나트륨

준비 용품

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid 공급 업체

글로벌( 98)공급 업체

공급자	전화	이메일	국가	제품 수	이점
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22963	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49374	58
career henan chemical co	+86-0371-86658258 +8613203830695	factory@coreychem.com	China	29810	58
TargetMol Chemicals Inc.	+1-781-999-5354 +1-00000000000	marketing@targetmol.com	United States	32161	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
CR Corporation Limited	+8613062833949	fred.wen@crcorporation.cn	China	8647	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58
ShenZhen Trendseen Biological Technology Co.,Ltd.	13417589054	trendseenbio@gmail.com	China	11681	58
GIHI CHEMICALS CO.,LIMITED	+8618058761490	info@gihichemicals.com	China	49980	58
Wuhan Topule Biopharmaceutical Co., Ltd	+8618327326525	masar@topule.com	China	8467	58

cis-4-[(4-Chlorophenyl)sulfonyl]-4-(2,5-difluorophenyl)cyclohexanepropanoic acid 관련 검색:

4-Chloroaniline Chlorobenzene Semagacestat DAPT Avagacestat (BMS-708163) LY411575 RO4929097 DIBENZAZEPINE