tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate
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tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate 속성
- 끓는 점
- 434.4±45.0 °C(Predicted)
- 밀도
- 1.09±0.1 g/cm3(Predicted)
- 저장 조건
- 2-8°C(protect from light)
- 물리적 상태
- 고체
- 물리적 상태
- 단단한 모양
- 산도 계수 (pKa)
- 11.90±0.60(Predicted)
- CAS 데이터베이스
- 365998-36-3
안전
- 위험 및 안전 성명
- 위험 및 사전주의 사항 (GHS)
그림문자(GHS): |
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신호 어: | Warning | ||||||||||||||||||||||||||||
유해·위험 문구: |
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예방조치문구: |
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tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate C화학적 특성, 용도, 생산
개요
Tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate is a pharmaceutical intermediate compound used in the preparation of Edoxaban. Edoxaban is an oral anticoagulant drug used for the treatment of strokes due to blood clots, thrombosis, heart disease and cirrhosis of the liver.용도
Tert-butyl(1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate is an organic synthesis intermediates and pharmaceutical intermediates, which can be used in laboratory research and development processes and chemical and pharmaceutical synthesis processes. It is a reagent used in the synthesis of cis-1,2-diaminocyclohexane derivative. It is also mainly used as raw material to synthesize reversible factor Xa inhibitor drug edoxaban[1]. The drug has been approved by the U.S. Food and Drug Administration as a direct oral anticoagulant and is the fourth direct oral anticoagulant approved for clinical use[2-3].Referance:[1] Frantisek Nehaj, Juraj Sokol, Jela Ivankova, Michal Mokan, Marian Mokan, Jan Stasko, Edoxaban affects TRAP-dependent platelet aggregation, Journal of Thrombosis and Thrombolysis, 2020, 49, 578-583.
[2] Juraj Sokol, Frantisek Nehaj, Jela Ivankova, Michal Mokan, Lenka Lisa, Jana Zolkova, Lubica Vadelova, Marian Mokan, Jan Stasko, Impact of Edoxaban on Thrombin-Dependent Platelet Aggregation,Clinical and Applied Thrombosis/Hemostasis, 2020.
[3] Mara Poulakos, Jacqueline N Walker, Umima Baig, Tosin David, Edoxaban: A direct oral anticoagulant, American Journal of Health-System Pharmacy, 2017,74, 117–129.
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate 준비 용품 및 원자재
원자재
Edoxaban Impurity 16
(1S,4S,5S)-4-Bromo-6-oxabicyclo[3.2.1]octan-7-one
(1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate
카르밤산,n-[(1r,2r,5s)-5-[(디메틸아미노)카르보닐]-2-히드록시시클로헥실]-,1,1-디메틸에틸에스테르
(1S,3R,4R)-3-amino-4-hydroxy-N,N-dimethylcyclohexanecarboxamide
디 -Tert- 부틸 디 카보네이트
(1S,3S,6R)-N,N-dimethyl-7-oxabicyclo[4.1.0]heptane-3-carboxamide
준비 용품
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate 공급 업체
글로벌( 184)공급 업체
공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
---|---|---|---|---|---|
Eaglech(shanghai)Pharmaceutical Co., Ltd | +8613884467586 |
info@distant-chem.com | China | 8 | 58 |
Zhuhai Hairuide Bioscience and Technology Co., Ltd | +8618928027945 |
sales3@zhhairuide.com | China | 97 | 58 |
Anhui Ruihan Technology Co., Ltd | +8617756083858 |
daisy@anhuiruihan.com | China | 994 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 |
sales@capotchem.com | China | 29798 | 60 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 |
info@tianfuchem.com | China | 21668 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 |
jack.li@time-chemicals.com | China | 1807 | 55 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
sales@coreychem.com | China | 29894 | 58 |
SHANDONG ZHI SHANG CHEMICAL CO.LTD | +86 18953170293 |
sales@sdzschem.com | China | 2931 | 58 |
Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 |
figo.gao@foxmail.com | China | 7621 | 58 |
HubeiwidelychemicaltechnologyCo.,Ltd | 18627774460 |
faith@widelychemical.com | CHINA | 742 | 58 |
tert-butyl (1R,2S,5S)-2-aMino-5-(diMethylcarbaMoyl)cyclohexylcarbaMate 관련 검색:
Rivaroxaban
Donepezil
Edoxaban (TsOH salt)
edoxaban
2-Amino-5-chloropyridine
Edoxaban Impurity 8
N-(5-Chloropyridin-2-yl)oxalaMic acid ethyl ester
Oxalic acid 1-ethyl ester
5-Methyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridine-2-carboxylic acid hydrochloride
Tert-Butyl(1R,2S,5S)-2-azido-5-[(dimethylamino)carbonyl]cyclohexylcarbamate oxalic acid
tert-Butyl [(1R,2S,5S)-2-amino-5-[(dimethylamino)carbonyl]cyclohexyl]carbamate oxalate
Ethyl 2-((5-chloropyridin-2-yl)amino)-2-oxoacetate hydrochloride
(1R,2R,4S)-2-[(tert-butoxycarbonyl)aMino]-4-[(diMethylaMino)carbonyl]cyclohexyl Methanesulfonate
Acetic acid, [(5-chloro-2-pyridinyl)aMino]oxo-
480450-71-3
Edoxaban Impurity 37
Edoxaban Impurity 12 (1R,2R,4S)
2-Amino-3-chloropyridine