b-AP15
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b-AP15 속성
- 끓는 점
- 670.4±55.0 °C(Predicted)
- 밀도
- 1.416±0.06 g/cm3(Predicted)
- 산도 계수 (pKa)
- -1.39±0.20(Predicted)
안전
b-AP15 C화학적 특성, 용도, 생산
효소 저해제
This deubiquitinase inhibitor (FW = 421.31 g/mol; CAS 1009817-63-3), also named 3,5-bis[ (4-nitrophenyl) methylene]-1- (1-oxo-2-propen-1-yl) - (3E,5E) -4-piperidinone, targets two proteasome-associated ubiquitin carboxyl-terminal hydrolase-14, or USP14, and Ubiquitin Carboxyl-terminal Hydrolase isozyme L5 UCHL5, IC50 = 2.1 μM, resulting in a rapid accumulation of high-molecular-weight ubiquitin conjugates and functional shutdown of proteasome. Interestingly, b-AP15 displays several differences with respect to bortezomib including insensitivity to over-expression of the anti-apoptotic mediator Bcl-2 and anti-tumor activity in solid tumor models. Inhibition of DUBs blocked the processing and release of interleukin IL-1β in both mouse and human macrophages. DUB activity was necessary for inflammasome association as DUB inhibition also impaired ASC oligomerization and caspase-1 activation without directly blocking caspase- 1 activity. These data reveal the requirement for DUB activity in a key reaction of the innate immune response and highlight the therapeutic potential of DUB inhibitors for chronic auto-inflammatory diseases. (See also Bortezomib, Eeeyarestatin I)b-AP15 준비 용품 및 원자재
원자재
준비 용품
b-AP15 공급 업체
글로벌( 55)공급 업체
| 공급자 | 전화 | 이메일 | 국가 | 제품 수 | 이점 |
|---|---|---|---|---|---|
| MedChemexpress LLC | 021-58955995 |
sales@medchemexpress.cn | United States | 4863 | 58 |
| SPIRO PHARMA | |
eric_feng1954@126.com | China | 9254 | 55 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 |
klq@cw-bio.com | China | 3732 | 55 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 |
wj520wjxby@126.com | China | 1838 | 55 |
| Shanghai Zeye Biotechnology Co., Ltd. | 021-61998551 13122364865 |
sale1@shzysw.net | China | 9771 | 58 |
| Chunchuang (Wuhan) Technology Co., Ltd | 15342225168 |
yutianchun2007@126.com | China | 10001 | 58 |
| Wuhan Yanzhe Technology Co., Ltd | 15527250409 |
wenhaotian12@163.com | China | 4577 | 58 |
| Energy Chemical | 021-58432009 400-005-6266 |
marketing@energy-chemical.com | China | 44941 | 58 |
| Wuhan Shanhai Zhihe Biotechnology Co., Ltd. | 17771424646 |
shoubull@126.com | China | 967 | 58 |
| bioleaper | 18601717983 |
guojing@bioleaper.com | China | 5616 | 58 |